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GenomicsH3K4me3 modification analysis comparing Lsh WT and Lsh-/- MEFs
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and contribute to genome-wide methylation patterns remain elusive. Here, we report a hi...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-29393 | biostudies-arrayexpress
UnknownTwenty-five year occupational homicide mortality trends in North Carolina: 1992-2017.
Not available
S-EPMC11322415 | biostudies-literature
UnknownEssential Oil Composition and Bioactivity of Two Juniper Species from Bulgaria and Slovakia.
Not available
S-EPMC8232667 | biostudies-literature
ProteomicsWhole Proteomics of 24 hr pan Pim kinase inhibitor treatment of IL2 cultured CD8 T cells
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051214 | Pride
Lc-msms Pim447 Azd1208 Tofacitinib Mouse Pim1 Pim2 Cd8 t cell Cytotoxic t lymphocyte Pim kinase 
TranscriptomicsApple miRNAs and tasiRNAs with novel regulatory networks
Background miRNAs and their regulatory functions have been extensively characterized in model species but whether apple has evolved similar or unique regulatory features remains unknown. Results We performed deep sRNA-seq and identified 23 conserved, 10 less-conserved and 42 apple-specific miRNAs o...
ORGANISM(S): Malus x domestica 
2012-05-29 | E-GEOD-36065 | biostudies-arrayexpress
UnknownFour-Year Visual Outcomes in the Protocol W Randomized Trial of Intravitreous Aflibercept for Prevention of Vision-Threatening Complications of Diabetic Retinopathy.
Not available
S-EPMC10408259 | biostudies-literature
UnknownTemporal Changes on Postgadolinium MR Vessel Wall Imaging Captures Enhancement Kinetics of Intracranial Atherosclerotic Plaques and Aneurysms.
Not available
S-EPMC11392371 | biostudies-literature
ProteomicsConcomitant deletion of Shp-1 and Shp-2 in T cells fails to improve anticancer responses 
Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as programmed cell death protein 1 (PD-1). Blockade of PD-1 signalling leads to T cell reinvigoration and is increasingly applied as an effective anticancer treatment...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-29 | PXD034897 | Pride
Shp-2  shp-1  ptpn11  ptpn6  t cell exhaustion  cancer immunotherapy  inhibitory receptors  pd-1 checkpoint therapy  
TranscriptomicsUnveiling the transcriptional features associated with coccolithovirus infection of natural Emiliania huxleyi blooms.
Lytic viruses have been implicated in the massive cellular lysis observed during algal blooms, through which they assume a prominent role in oceanic carbon and nutrient flows. Despite their impact on biogeochemical cycling, the transcriptional dynamics of these important oceanic events is still poor...
ORGANISM(S): marine metagenome 
2011-11-22 | E-GEOD-24341 | biostudies-arrayexpress
UnknownSIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation
Not available
S-EPMC10217433 | biostudies-literature
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