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During embryonic development, the cerebral cortex is equipped with excitatory projection and inhibitory interneurons that migrate in organized layers. Periventricular heterotopia (PH) is a rare and heterogeneous disorder in which a subpopulation of new-born projection neurons fails to initiate their...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD015571 | Pride
Extracellular vesicles have been the center of many studies focusing on neuron-to-neuron communication while the role of EVs in progenitor-to-neuron and -astrocyte communication occurring during brain development has not been systematically investigated. In this project, we focus on the physiologica...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD028438 | Pride
Basal radial glial cells (bRGs) are neural progenitors enriched in primates and humans and were proposed to contribute to the expansion of neurons during cortical development in gyrencephalic species. Shortly after their generation, bRGs delaminate towards the outer subventricular zone, where they d...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-10-26 | PXD015878 | Pride
Periventricular heterotopia (PH), the most common form of grey matter heterotopia, represents a cortical malformation that is often associated with developmental delay and drug-resistant seizures1,2. The detailed neurophysiological underpinnings of PH symptoms in humans remain, however, elusive. Hum...
ORGANISM(S): Homo sapiens (Human) 
2025-01-13 | PXD038760 | Pride
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