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ProteomicsReticular fibroblasts counteract radiotherapy-induced head and neck tumor regression through Tenascin-C
Head and neck squamous cell carcinoma (HNSCC) patients have a very short survival. To improve patient survival, there is an emerging need for a better understanding of the obstacles of ionizing irradiation (IR), besides surgery, currently the best treatment option for HNSCC. A confounding factor is ...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-14 | PXD060164 | Pride
Tenascin-c Radiotherapy Reticular fibroblasts Tumor 
ProteomicsMulti-OMICS data of a Hyper IgD Syndrome family
The aim of this study was to understand why two siblings carrying both the same homozygous causal mutation for the auto-inflammatory disease hyper IgD show opposite phenotypes, i.e. the first being asymptomatic, the second presenting all classical characteristics of the disease. As compared to studi...
ORGANISM(S): Homo sapiens (Human) 
2019-10-24 | PXD009063 | Pride
Proteogenomics analysis - differential analysis - hyper igd syndrome - single amino acid variant characterization 
ProteomicsN2-methylguanosine modifications on human tRNAs and snRNA U6 are important for colon cancer cell proliferation, protein translation and pre-mRNA splicing
Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent an important layer of gene expression regulation through their ability to fine-tune mRNA maturation and transla-tion. Growing evidences support important roles of tRNA/snRNAs modifications and hence the enzymes that install...
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD038967 | Pride
Ap-ms experiment 
ProteomicsN2-methylguanosine modifications on human tRNAs and snRNA U6 are important for colon cancer cell proliferation, protein translation and pre-mRNA splicing
Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent an important layer of gene expression regulation through their ability to fine-tune mRNA maturation and transla-tion. Growing evidences support important roles of tRNA/snRNAs modifications and hence the enzymes that install...
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD038997 | Pride
Bioid experiment 
ProteomicsCombining label-free and label-based accurate quantifications with SWATH-MS: comparison with SRM and PRM for the evaluation of bovine muscle type effects
The performances of label-based SWATH-MS, SRM and PRM to accurately quantify ten candidate biomarkers of beef meat tenderness or marbling, in a cohort of 64 bovine muscle tissues expected to cover a wide biological range of these traits, were evaluated. Limits of quantification, dynamic range and qu...
ORGANISM(S): Bos taurus (Bovine) 
2021-06-09 | PXD020638 | Pride
Beef meat quality  data-independent acquisition (dia)  quantitative ms  swath-ms  targeted proteomics 
ProteomicsTenascin-C shapes TRAIL control over tumor immunity
TRAIL cytotoxicity is exploited as anti-cancer therapy since many years, however incomplete knowledge is generating many obstacles. Here, we address whether the highly abundant extracellular matrix molecule tenascin-C (TNC) orchestrating an immune suppressive tumor microenvironment and binding TRAIL...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-15 | PXD045388 | Pride
Shotgun proteomics Tenascin c Trail Maremo peptide mp5 
ProteomicsQuantitative proteomic profiling of Arabidopsis nuclei reveals accumulation of nucleolar proteins after a prolonged heat stress
Heat stress (HS) impacts the nuclear proteome and, subsequently, protein activities in the nucleoplasm and/or different nuclear compartments. In Arabidopsis thaliana, a short exposure to 37°C leads to the loss of the standard tripartite architecture of the nucleolus, the most prominent nuclear subst...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-10-17 | PXD045038 | Pride
Nanolc-msms Heat stress Nucleolus Nucleus 
ProteomicsMultiomics analyses reveal B cell differentiation arrest and neutrophil hypogranulation in a patient with an immunodeficiency caused by a novel homozygous missense variant in HYOU1
The Hypoxia Upregulated Protein 1 (HYOU1) encodes an endoplasmic reticulum chaperone which is expressed in response to endoplasmic reticulum stress and contributes to cellular protection by restoring cell homeostasis. In this study, we report a patient with a novel homozygous variant in HYOU1 (NM_00...
ORGANISM(S): Homo sapiens (Human) 
2026-08-18 | PXD058947 | Pride
B cell deficiency Multiomics Neutrophil hypogranulation Hyou1 Immunodeficiency 
ProteomicsAccelerated aging modulates the toxicological properties of the diazo tattoo pigment Po13
Pigment particles used in tattooing may exert long terms effect by releasing diffusible degradation products. In the present work, aqueous suspensions of the organic orange pigment Po13 were aged by exposure to simulated sunlight at 40°C. The morphology and the surface charge of Po13 particles were ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056061 | Pride
Tattoo Skin toxicity Nanolc-ms/ms 
ProteomicsA de novo mutation in /ITPR3/ causes combined immunodeficiency
This study reports two unrelated patients with a combined immunodeficiency. Whole-exome sequencing of both patients, their healthy parents and siblings identified in both families a /de novo/ missense variant in /ITPR3/ (NM_002224.3:c.7570C>T, p.Arg2524Cys). While the mRNA level in patients remained...
ORGANISM(S): Homo sapiens (Human) 
2024-06-18 | PXD038284 | Pride
Shotgun proteomics Rnaseq Itpr3 mutation Immunophenotying 
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