Sort   by:  
 Page size 
Proteomicsroad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy
Myosin inhibitor mavacamten is the first targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcomeric myosin and its negative regulator cardiac myosin-binding protein C (cMyBP-C, encoded by MYBPC3). Here, we have ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-02 | PXD076207 | Pride
Hypertrophic cardiomyopathy Myosin inhibition 
GenomicsAmino terminus of cardiac myosin binding protein-C regulates cardiac contractility
Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility
PRJNA716300 | ENA
ProteomicsIdentification of phosphorylation and other post-translational modifications in the central C4-C5 domains of murine cardiac myosin binding protein C
Cardiac myosin binding protein C (cMyBPC) is a critical multidomain protein that modulates myosin cross bridge behavior and cardiac contractility. cMyBPC is principally regulated by phosphorylation of the residues within the M-domain of its N-terminus. However, not much is known about the phosphoryl...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-04 | PXD031262 | Pride
Post translational modification Cardiac myosin binding protein c Mass spectrometry 
ProteomicsCharacterization of the Cardiac Myosin Binding Protein-C Phosphoproteome in Healthy and Failing Human Hearts
Introduction: Cardiac myosin binding protein-C (cMyBP-C) becomes dephosphorylated in the failing heart and reduced phosphorylation-dependent regulation of cMyBP-C has been implicated in contractile dysfunction. To date, several phosphorylation sites have been identified for human cMyBP-C; however, ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2013-05-01 | PXD000158 | Pride
Phosphoprotein Phosphoproteome Mass spectrometry Cardiac myosin binding protein c Cmybpc Cardiac 
GenomicsFast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure
Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure
PRJNA1477636 | ENA
ProteomicsHuman MyBP-C PKA-treated C0-C2 LC-MSMS
Cardiac myosin-binding protein C (cMyBP-C) is a thick filament–associated protein that influences actin–myosin interactions. cMyBP-C alters myofilament structure and contractile properties in a protein kinase A (PKA) phosphorylation–dependent manner. To determine the effects of cMyBP-C and its phosp...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD015391 | Pride
Human Lc-msms Myosin binding protein c Cmybp-c Phosphorylated Pka C0-c2 C0c2 
TranscriptomicsThe AP-1 Transcription Factor c-Jun Prevents Stress-Imposed Maladaptive Remodeling of the Heart
Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response) through expansion of sarcomeres with the aim to increase contractility. However, conditions of increased workload can induce both adaptive and ma...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-47898 | biostudies-arrayexpress
TranscriptomicsFast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure
RNA sequencing was performed to investigate the role of fast skeletal myosin binding protein-C (fMyBP-C) in cardiac pathology and heart failure. fMyBP-C, a paralog of cardiac myosin binding protein-C (cMyBP-C), is upregulated in diseased mouse hearts. To determine its functional consequences, we gen...
ORGANISM(S): Mus musculus 
2026-09-30 | GSE335235 | GEO
ProteomicsFast skeletal myosin binding protein-C regulates fast skeletal muscle contraction
Myosin-binding protein C (MyBP-C) is a thick filament regulatory protein found exclusively in the C-zone of the A band in the sarcomeres of vertebrate striated muscle. Cardiac, slow skeletal and fast skeletal MyBP-C (fMyBP-C) paralogs perform different functions. However, the functional role of fMyB...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-09 | PXD022316 | Pride
Lc ms/ms Proteomics Skeletal myosin binding protein-c Muscle 
TranscriptomicsAmino terminus of cardiac myosin binding protein-C regulates cardiac contractility
Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) regulates cardiac contraction through modulation of actomyosin interactions mediated by the protein’s amino terminal (N’)-region (C0-C2 domains, 358 amino acids). On the other hand, dephosphorylation of cMyBP-C during myocardial injury re...
ORGANISM(S): Mus musculus 
2021-03-23 | GSE169340 | GEO
Sort   by:  
 Page size