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TranscriptomicsIntegrative DNA, RNA and protein evidence connects TREML4 to coronary artery calcification
Peripheral blood RNA-Seq from human coronary artery calcification cases and controls; Coronary artery calcification (CAC) is a heritable and definitive morphologic marker of atherosclerosis that strongly predicts risk for future cardiovascular events. To search for genes involved in CAC, we used an ...
ORGANISM(S): Homo sapiens 
2014-06-10 | E-GEOD-58150 | biostudies-arrayexpress
TranscriptomicsmRNA expression profile in vascular smooth muscle cells (VSMCs) after inducing calcification
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced polyubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activi...
ORGANISM(S): Rattus norvegicus 
2015-11-07 | E-GEOD-74755 | biostudies-arrayexpress
ProteomicsComputational Prediction, Validation and Repurposing of Existing Drug as Inhibitor of Vascular Calcification
This study aimed to identify small molecules that inhibit vascular calcification with computational approach. To examine the mechanism of calcification inhibition, proteomics analysis was performed using aorta tissue samples to clarify therapeutic target.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029963 | Pride
Vascular calcification Proteomics Mice Wnt signaling Drug discovery Drug repurposing 
TranscriptomicsThe effect of homocysteine on human aortic smooth muscle cells
Vascular calcification is a common manifestation of atherosclerosis and involves cell-mediated processes similar to the formation of bone (osteogenesis). Elevated plasma levels of homocysteine are an independent risk factor for atherosclerotic vascular disease but the underlying mechanisms remain un...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-9490 | biostudies-arrayexpress
ProteomicsCarnitine O-octanoyltransferase is a novel inducer of vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction
Objective – Vascular calcification is a critical pathology associated with increased cardiovascular event risk, but there are no FDA-approved anti-calcific therapies. We hypothesized and validated that an unbiased screening approach would identify novel mediators of human vascular calcification. Ap...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD022575 | Pride
Human primary smooth muscle cells Crot Cardiovascular calcification 
ProteomicsA Proteomic Atlas of Atherosclerosis: Regional Proteomic Signatures for Plaque Inflammation and Calcification
Background: Using proteomics, we strove to reveal novel molecular subtypes of human atherosclerotic lesions, study their associations with histology and imaging and relate them to long-term cardiovascular outcomes. Methods: 219 samples were obtained from 120 patients undergoing carotid endarterectom...
ORGANISM(S): Homo sapiens (Human) 
2023-11-15 | PXD031052 | Pride
Calcification Tmt-labelling Plaque Cardiovascular outcome prognosis Atherosclerosis Inflammation Carotid endarterectomy 
ProteomicsMitochondrial extracellular vesicles promote aortic valve calcification via carnitine O-octanoyltransferase
Calcific aortic valve disease (CAVD) is a leading cause of cardiovascular morbidity and mortality with no effective medical therapy. We previously identified carnitine O-octanoyltransferase (CROT) as a mediator of mitochondrial dysfunction and vascular calcification. However, its role in CAVD remain...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-05-13 | PXD072508 | Pride
Mitochondrial extracellular vesicles Aortic valve calcification Mitochondria Valvular interstitial cells Lc-ms/ms 
ProteomicsIndoxyl sulfate and p-cresyl sulfate directly promote vascular calcification via activation of inflammation and coagulation pathways
Vascular calcification contributes to high cardiovascular mortality in chronic kidney disease (CKD) patients. An association between the uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (PCS) and cardiovascular disease has been suggested. This study provides strong etiological evidence for in...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-06-13 | PXD012582 | Pride
Indoxyl sulfate Chronic kidney disease Vascular calcification Inflammation Hyperglycemia Coagulation P-cresyl sulfate Itraq-8plex 
ProteomicsSerum Alpha-2-Macroglobulin Links Type 1 Diabetes Status and Incident Cardiovascular Disease
Background: Cardiovascular disease (CVD) is a leading cause of mortality in individuals with type 1 diabetes mellitus (T1DM), with conventional risk factors not fully explaining the heightened risk. Study Design: We conducted a cross-sectional study comparing serum protein levels in 134 participants...
ORGANISM(S): Homo Sapiens 
2025-02-11 | PXD054039 | panorama
UnknownInduced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification.
Not available
S-EPMC9357895 | biostudies-literature
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