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INTRODUCTION: Oats (Avena sativa L.) are a whole grain cereal recognised for their health benefits and which are cultivated largely in temperate regions providing both a source of food for humans and animals, as well as being used in cosmetics and as a potential treatment for a number of...
2020-06-11 | MTBLS804 | MetaboLights
INTRODUCTION: Blackcurrant (Ribes nigrum L.) is an excellent example of a “super fruit” with potential health benefits. Both genotype and cultivation environment are known to affect the chemical composition of blackcurrant, especially ascorbic acid and various phenolic compounds. Environmental condi...
2019-02-12 | MTBLS773 | MetaboLights
Muscle and adipose tissue insulin resistance are major drivers of metabolic disease. To uncover pathways involved in insulin resistance specifically in these tissues, we leveraged the metabolic diversity of different dietary exposures and discrete inbred mouse strains. This revealed that muscle insu...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-24 | PXD029680 | Pride
This study explored the proteomic basis of cold adaptation, quantifying 11,394 proteins across 6 metabolic tissues and plasma. Systems level analysis revealed an enrichment for proteins involved in metabolism. In brown adipose tissue (BAT), cold adaptation was associated with enhanced glucose utilis...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD055965 | Pride
Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. “Diversity Outbred in Australia (DOz)” is a population of genetically unique mice with profound metabolic heterogeneity. We leveraged this variance...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-31 | PXD042277 | Pride
This project aimed to identify proteins copurifying with the Kv2.1 potassium channel from lysates prepared from crosslinked mouse brain homogenates. Comparison samples were prepared from Kv2.1 knockout mouse brains. Parallel immunopurifications were perfofmed for the unrelated Kv1.2 potassium chann...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-30 | PXD044574 | Pride
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