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TranscriptomicsChromatin immunoprecipitation of estrogen receptor in human breast cancer cells (MCF-7) treated with estrogen
Cross talk between the Estrogen Receptor (ER) and ErbB2/HER-2 pathways have long been implicated in breast cancer aetiology and drug response1, yet no direct connection at a transcriptional level has been shown. We now show that estrogen-ER and tamoxifen-ER complexes directly repress ErbB2 transcrip...
ORGANISM(S): Homo sapiens 
2008-09-27 | E-TABM-563 | biostudies-arrayexpress
TranscriptomicsGATA3 acts upstream of FOXA1 in mediating ER binding by shaping enhancer accessibility
Estrogen Receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences in enhancer occupancy by ESR1, contribute to the diverse expression profiles and clinical outcome observed in brea...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-39623 | biostudies-arrayexpress
GenomicsGATA3 acts upstream of FOXA1 in mediating ER binding by shaping enhancer accessibility
Estrogen Receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences in enhancer occupancy by ESR1, contribute to the diverse expression profiles and clinical outcome observed in brea...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-40129 | biostudies-arrayexpress
UnknownClinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients.
Not available
S-EPMC3731981 | biostudies-literature
TranscriptomicsEffects of pulp and paper mill effluents on gene expression in the fathead minnow hypothalamus
We evaluated the possible mechanisms by which exposures to pulp and paper mill effluents gene expression in the fathead minnow hypothalamus Keywords: Toxicology Sexually mature fathead minnows were exposed to 100% pulp and paper mill effluents for 5 days. Tanks contained 4 females and 2 males. A ...
ORGANISM(S): Pimephales promelas 
2010-07-07 | E-GEOD-17130 | biostudies-arrayexpress
ProteomicsER/PR RIME Experiments in MCF7 and T47D cell lines
Immuno-precipitation followed by MS was performed using the RIME protocol in this study. Estrogen Receptor (ER) and Progestorone Receptor (PR) were targetted using antibodies. The experiments were performed in a quantitative manner using SILAC labelling. Cells grown in complete serum (estrogenic) co...
ORGANISM(S): Homo sapiens (Human) 
2015-05-26 | PXD002104 | Pride
Pr Rime Estrogen receptor Progesterone receptor Er 
ProteomicsARID1A RIME in human cell lines and tissue xenografts.
Examination of chromatin-bound proteins associated with ARID1A, BRG1 and ERa in MCF7 cells and ERa in ER+ patient-derived xenografts using RIME protocol and mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2019-10-31 | PXD011810 | Pride
Human Arid1a Rime Qplex 
ProteomicsHNF4G and FOXA1 are context-specific drivers of pancreatic cancer progression
Despite recent advances in the treatment of pancreatic adenocarcinoma (PDAC), clinical outcome remains poor. Previous evidence linked the pioneer transcription factor FOXA1 as a mediator of new regulatory elements that drive tumour progression in models of late-stage disease. Given the critical role...
ORGANISM(S): Homo sapiens (Human) 
2025-08-13 | PXD045980 | Pride
Foxa1 Pancreatic adenocarcinoma Hnf4g Rime 
UnknownEpigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score.
Not available
S-EPMC3918538 | biostudies-literature
TranscriptomicsGene expression profiles induced by knockdown and overexpression of p63 variants in MCF-10A mammary epithelial cell line
p63 is critical for epithelial development yet little is known about the transcriptional programmes it regulates. The p63 transactivating (TA) isoforms contain an amino-terminal exon that encodes a p53-like transactivation domain, whereas ΔN-isoforms lack this domain but contain the common DNA bind...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20286 | biostudies-arrayexpress
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