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ProteomicsSchwann cell plasticity regulates neuroblastic tumor cell differentiation
The remarkable plasticity of Schwann cells (SCs) is essential for nerve regeneration but also contributes to neuropathies and cancer progression. It has not yet been investigated whether the adaptive potential of SCs is manifested in stromal, tumor associated SCs characteristically found within a be...
ORGANISM(S): Homo sapiens (Human) 
2021-01-13 | PXD018267 | Pride
Neuroblastoma Plasticity Ganglioneuroma Schwann cell Egfl8 Stroma 
TranscriptomicsRNA-seq of in vitro differentiation of human embryonic stem cells into cortical neurons over 77 days
Many neurological and psychiatric disorders affect the cerebral cortex, and a clearer understanding of the molecular processes underlying human corticogenesis will provide greater insight into such pathologies. To date, knowledge of gene expression changes accompanying corticogenesis is largely base...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-56796 | biostudies-arrayexpress
GenomicsGene Expression Signatures in CATHGEN

Case control cohort: The details have been previously published: American Heart Journal. 2010;160:371-379 e372. Briefly, a nested case:control cohort of CATHGEN participants who had experienced death or MI (n = 250) after their index catheterization and age-, sex-, and race-matched controls (n = ...

phs000551.v1.p1 | EGA
TranscriptomicsOverexpression of USF1 in HEK293T cells
Overexpression of USF1 in HEK293T cells in vitro to ascertain the genes downstream of USF1. Will identify direct targets as well as indirect targets of USF1. Keywords: Overexpression of transcription factor to determine downstream targets. Cloned USF1 from cDNA and transiently transfected into HEK2...
ORGANISM(S): Homo sapiens 
2009-09-14 | E-GEOD-17300 | biostudies-arrayexpress
ProteomicsActive Site Specificity Profiling of the Matrix Metalloproteinase Family: Proteomic Identification of 4,300 Cleavage Sites by MMPs 1, 2, 3, 7, 8, 9, 12, 13, and 14.
Background: The active site of matrix metalloproteinases (MMPs) is highly conserved, complicating the rational design of specific substrates and inhibitors for individual family members. Results: Active site specificity profiles of 9 MMPs were determined using high throughput Proteomic Identificatio...
ORGANISM(S): Homo sapiens (Human) 
2015-09-29 | PXD002265 | Pride
Ecm Pics Mmps Mass spectrometry Specificity profiling Webpics 
GenomicOncoArray: Prostate Cancer

Original description of the study: From ELLIPSE (linked to the PRACTICAL consortium), we contributed ~78,000 SNPs to the OncoArray. A large fraction of the content was derived from the GWAS meta-analyses in European ancestry populations (overall and aggressive disease; ~27K SNPs). We also ...

phs001391 | dbGaP
TranscriptomicsFDB1_GM-CSFTyr577_Receptor_Mutant_Factorial_Time_Course_Study
To understand better the mechanisms controlling the balance between proliferation and and differentiation during myelopoiesis we have utilized teh bi-potent FDB1 myeloid cell line which differentiates to granulocytes and macrophages in response to GM-CSF and thus provides a dissectable model to anal...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-25857 | biostudies-arrayexpress
GenomicsGenetic Heterogeneity of Diffuse Large B Cell Lymphoma

We sequenced exomes of 94 DLBCL tumors and cell lines. 34 of the tumors had paired normal tissue. Our work elucidates commonly occurring gene-coding mutations in DLBCL.

phs000573.v1.p1 | EGA
GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE)

By relating hundreds of thousands of genotypes to only a few phenotypes, mostly in individuals of one ancestry, genome-wide association (GWA) studies are identifying a rapidly growing number of associations. The Population Architecture using Genomics and Epidemiology (PAGE) Study is designed to f...

phs000356.v1.p1 | EGA
GenomicsGenome Sequencing of Pancreatic Ductal Adenocarcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)

Pancreatic ductal adenocarcinomas (PDAC) is the 11th most common cancer in the USA but the 4th in fatalities. The onset and progression of cancer is driven by extensive rearrangement and mutation of the genome. We combined our capability to capture and enrich exome DNA with the next generation se...

phs000516.v1.p1 | EGA
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