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ProteomicsInterferon-induced degradation of the hepatitis B virus persistence form, cccDNA, depends on ISG20
Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available antivirals. Cytokine treatments can diminish HBV cccDNA via APOBEC3-mediated deamination. Here we show that overexpression of APOBEC3A alone,...
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD019285 | Pride
Isg20 Apobec3a Hbv Interferon-gamma Cccdna Chronic hepatitis b Interferon-alpha 
GenomicsBinding of Nucleolin to HBV cccDNA
Binding of Nucleolin to HBV cccDNA
PRJNA509631 | ENA
ProteomicsIdentification of cellular protein interacting with HBV genome by protein mass spectrometry
: Hepatitis B virus (HBV) remains a major public health threat with more than 296 million people chronically infected worldwide at high risk to develop hepatocellular carcinoma. Current therapies are effective in suppressing HBV replication but rarely lead to cure. The fundamental limitation rests o...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD042733 | Pride
Hbv cccdna Mini-chromosome Transcription Therapy 
GenomicsHepatitis B virus core protein is not required for cccDNA transcriptional regulation
Hepatitis B virus core protein is not required for cccDNA transcriptional regulation
PRJNA821068 | ENA
UnknownMinicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs.
Not available
S-EPMC5098228 | biostudies-literature
GenomicsHBV cccDNA Generated Using Single-Stranded M13 Phage DNA for Authentic Minichromosome Functionality
HBV cccDNA Generated Using Single-Stranded M13 Phage DNA for Authentic Minichromosome Functionality
PRJNA1234531 | ENA
GenomicsBinding of Nucleolin to HBV cccDNA
Covalently closed circular DNA (cccDNA) forms the basis for replication and persistence of hepatitis B virus (HBV) in the chronically infected liver. In this study we sought to identify host factors interacting with the HBV genome. Nucleolin (Ncl) was identified as a potential interactor of HBV cccD...
ORGANISM(S): Homo sapiens 
2021-12-31 | GSE123715 | GEO
GenomicsCTCF regulates hepatitis B virus cccDNA chromatin topology [RNA-seq]
CTCF regulates hepatitis B virus cccDNA chromatin topology [RNA-seq]
PRJNA1048435 | ENA
GenomicsCTCF regulates hepatitis B virus cccDNA chromatin topology [ATAC-seq]
CTCF regulates hepatitis B virus cccDNA chromatin topology [ATAC-seq]
PRJNA1045688 | ENA
GenomicsHepatitis B virus core protein is not required for cccDNA transcriptional regulation
Background & Aims: Hepatitis B virus (HBV) infection is a major health burden worldwide and currently there is no cure. The persistence of HBV covalently closed circular DNA (cccDNA) is the major obstacle for antiviral treatment. HBV core protein (HBc) has merged as a promising antiviral target, as ...
ORGANISM(S): Hepatitis B virus Homo sapiens 
2022-04-01 | GSE199653 | GEO
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