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ProteomicsInterferon-induced degradation of the hepatitis B virus persistence form, cccDNA, depends on ISG20
Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available antivirals. Cytokine treatments can diminish HBV cccDNA via APOBEC3-mediated deamination. Here we show that overexpression of APOBEC3A alone,...
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD019285 | Pride
Isg20 Apobec3a Hbv Interferon-gamma Cccdna Chronic hepatitis b Interferon-alpha 
UnknownLnc-ISG20 Inhibits Influenza A Virus Replication by Enhancing ISG20 Expression.
Not available
S-EPMC6069214 | biostudies-literature
GenomicsEffect of ISG20 expression (wild-type or M1 mutant) on total RNA expression.
Effect of ISG20 expression (wild-type or M1 mutant) on total RNA expression.
PRJNA977999 | ENA
UnknownISG20 inhibits bluetongue virus replication.
Not available
S-EPMC9437527 | biostudies-literature
GenomicsThe interferon-induced exonuclease, ISG20, exerts antiviral activity through upregulation of type I interferon response proteins
The interferon-induced exonuclease, ISG20, exerts antiviral activity through upregulation of type I interferon response proteins
PRJNA475885 | ENA
GenomicsInterferon stimulated gene ISG20 induces an innate immune defense signature in primary human fibroblasts [RNA-Seq]
Interferon stimulated gene ISG20 induces an innate immune defense signature in primary human fibroblasts [RNA-Seq]
PRJNA1322531 | ENA
GenomicsInterferon stimulated gene ISG20 induces an innate immune defense signature in primary human fibroblasts [SLAM-seq]
Interferon stimulated gene ISG20 induces an innate immune defense signature in primary human fibroblasts [SLAM-seq]
PRJNA1322536 | ENA
GenomicsInterferon stimulated gene ISG20 induces an innate immune defense signature in primary human fibroblasts
Interferon stimulated gene ISG20 induces an innate immune defense signature in primary human fibroblasts
PRJNA1327132 | ENA
TranscriptomicsEffect of ISG20 expression (wild-type or M1 mutant) on total RNA expression.
ISG20 is an interferon-induced 3'-to-5' RNA exonuclease that acts as a broad antiviral innate defense factor. At present, the features that expose RNA to the action of ISG20 remain unclear. However recent studies have pinpointed to RNA epitranscriptomic modifications as modulators that either expose...
ORGANISM(S): Homo sapiens 
2023-06-01 | GSE233792 | GEO
UnknownISG20: an enigmatic antiviral RNase targeting multiple viruses.
Not available
S-EPMC9157404 | biostudies-literature
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