Sort   by:  
 Page size 
TranscriptomicsT-cell co-stimulation
Optimal activation of T cells requires effective occupancy of both the antigen-specific T cell receptor and a second coreceptor such as CD28. We used cDNA microarrays to characterize the genomic expression program in human peripheral T cells responding to stimulation of these receptors. We found tha...
ORGANISM(S): Homo sapiens 
2005-11-18 | E-GEOD-3630 | biostudies-arrayexpress
ProteomicsPhosphoproteomics quantitative characterization in Jurkat E6.1 and Jurkat Gamma1.
Phosphorylation is a reversible post-translational modification, playing a vital role in protein function. In T cells, protein phosphorylation is the key mechanism regulating T cell receptor – driven signaling pathways. In order to gain insights into the phosphoproteome evolution of T cell activatio...
ORGANISM(S): Homo sapiens (Human) 
2015-11-10 | PXD002871 | Pride
Phosphorylation Cd3/cd28 costimulation Quantitative phosphoproteomics. Jurkat t cells Phospholipase c gamma 1 
TranscriptomicsEffect of costimulation on microRNAs levels in human naïve CD4 T cells
microRNA transcriptional profiling of human naïve CD4 T cells comparing cells that saw no activation, only anti-CD3 or anti-CD3 and anti-CD28 to identify microRNAs specifically upregulated by CD28-mediated costimulation. Three conditions experiment. PBS, anti-CD3, anti-CD3 + anti-CD28 all compared t...
ORGANISM(S): Homo sapiens 
2012-02-25 | E-GEOD-36071 | biostudies-arrayexpress
GenomicsImpact of TNF receptor superfamily member costimulation on the transcriptome of in vitro CD3/CD28 activated mouse Tregs
Impact of TNF receptor superfamily member costimulation on the transcriptome of in vitro CD3/CD28 activated mouse Tregs
PRJNA609358 | ENA
TranscriptomicsCD4+T cells activation
Aanlysis of human resting CD4+T cells and cells activated by two different methods: CD4+ T cells unstimulated (be susceptible but not support to HIV-1) and stimulated either by CD3/CD28 costimulation (reversed susceptibility and resisted to HIV-1) or by PHA/IL-2 for six days (be susceptible and supp...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-34252 | biostudies-arrayexpress
ProteomicsTreg cells from human blood differentiate into non-lymphoid tissue-resident effector cells upon TNFR2 costimulation
Regulatory T (Treg) cells can facilitate transplant tolerance and attenuate autoimmune- and inflammatory diseases. Therefore, it is clinically relevant to stimulate Treg cell expansion and function in vivo and to create therapeutic Treg cell products in vitro. We report that TNF receptor 2 (TNFR2) i...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD048248 | Pride
Human Ttreg Tconv Tnfr2 Conventional t cell Cd28 Thymus-derived regulatory t cell Treg Regulatory t cell Costimulation 
TranscriptomicsTranscription profiling of human peripheral T cells responding to stimulation of antigen-specific T cell receptor and CD28
Optimal activation of T cells requires effective occupancy of both the antigen-specific T cell receptor and a second coreceptor such as CD28. We used cDNA microarrays to characterize the genomic expression program in human peripheral T cells responding to stimulation of these receptors. We found tha...
ORGANISM(S): Homo sapiens 
2005-09-23 | E-SMDB-748 | biostudies-arrayexpress
GenomicsEffect of costimulation on microRNAs levels in human naïve CD4 T cells
microRNA transcriptional profiling of human naïve CD4 T cells comparing cells that saw no activation, only anti-CD3 or anti-CD3 and anti-CD28 to identify microRNAs specifically upregulated by CD28-mediated costimulation.
ORGANISM(S): Homo sapiens Human alphaherpesvirus 1 Human betaherpesvirus 5 Betapolyomavirus hominis Mus musculus Rattus norvegicus Murid betaherpesvirus 1 JC polyomavirus Human immunodeficiency virus 1 Human gammaherpesvirus 8 Murid gammaherpesvirus 4 human gammaherpesvirus 4 Betapolyomavirus macacae 
2012-02-25 | GSE36071 | GEO
UnknownCD28 and CD3 have complementary roles in T-cell traction forces.
Not available
S-EPMC3926067 | biostudies-literature
GenomicsResponse of expanded human conventional and regulatory T cells to CD3/CD28-mediated activation [Exp1]
Response of expanded human conventional and regulatory T cells to CD3/CD28-mediated activation [Exp1]
PRJNA576498 | ENA
Sort   by:  
 Page size