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TranscriptomicsTranscriptional profiling using microarrays to elucidate the effects of partial whiB1 gene deletion in Mycobacterium tuberculosis H37Rv
DNA microarray analysis was performed on RNA from a strain of Mycobacterium tuberculosis H37Rv in which the essential whiB1 gene was deleted from the chromosome but partially complemented by a wild type allele on a plasmid, compared to RNA from H37Rv wild type containing the same plasmid.
ORGANISM(S): Mycobacterium tuberculosis 
2017-12-22 | E-MTAB-5814 | biostudies-arrayexpress
TranscriptomicsMaternal Bisphenol A effect on fetal heart and skeletal muscle gene expression
Compairsion of transcriptional profiles of heart and skeletal muscle tissue of fetal rhesus monkey exposed to maternal Bisphenol A or vehicle during early or late gestaion. Maternal exposure to the endocrine disrupting chemical, bisphenol A (BPA) affects the development of multiple organ systems in ...
ORGANISM(S): Macaca mulatta 
2014-07-01 | E-GEOD-53393 | biostudies-arrayexpress
ProteomicsTAILS N-terminomics of the human dental pulp stroma and the odontoblast layer
We report the targeted analysis of the human dental pulp stroma and the odontoblast layer using the positional proteomics technique TAILS N-terminomics, which allowed us to capture both naturally blocked and unblocked protein N-termini, and to identify differences between e.g. the dental pulp proteo...
ORGANISM(S): Homo sapiens (Human) 
2017-10-20 | PXD006557 | Pride
Human Chpp Positional proteomics Odontoblast Tails N-terminomics Lc-msms Pulp Stroma 
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
ProteomicsA protein microarray-based analysis of S-nitrosylation
Yeast protein microarrays were utilized to investigate determinants of S-nitrosylation by biologically relevant low-mass S-nitrosothiols (SNOs). Large numbers of S-nitrosylated yeast proteins were identified after treatment with SNOs, among which those with active-site Cys thiols residing at N termi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-19 | E-GEOD-19218 | biostudies-arrayexpress
TranscriptomicsDose-dependent effects of TCDD in juvenile rainbow trout
We investigated the effects of chronic TCDD exposure on global gene expression in developing rainbow trout (Oncorhynchus mykiss). Juvenile rainbow trout (0.18M-BM-10.01g) were fed Biodiet starter with TCDD added at 0, 0.1, 1, 10 and 100ppb, and ten fish were sampled and pooled from each group for mi...
ORGANISM(S): Oncorhynchus mykiss 
2013-04-05 | E-GEOD-45779 | biostudies-arrayexpress
TranscriptomicsTime-dependent toxic effects of dietary TCDD in juvenile rainbow trout
We investigated the effects of chronic TCDD exposure on global gene expression in developing rainbow trout (Oncorhynchus mykiss). Juvenile rainbow trout(0.18M-BM-10.01g) were fed Biodiet starter with TCDD added at 0, 0.1, 1, 10 and 100ppb, and ten fish were sampled and pooled from 10 ppb group at 7,...
ORGANISM(S): Oncorhynchus mykiss 
2013-04-05 | E-GEOD-45780 | biostudies-arrayexpress
UnknownInhibition of endogenous hydrogen sulfide production in clear-cell renal cell carcinoma cell lines and xenografts restricts their growth, survival and angiogenic potential.
Not available
S-EPMC4876030 | biostudies-literature
TranscriptomicsTranscriptomic profiling of Salmonella during lag, exponential and stationary phases of growth
Transcriptional profiles during all phases of growth of Salmonella Typhimurium SL1344 were obtained and used to investigate growth phase-dependent alterations in gene expression. Viable count growth curve analysis of the growth system showed a culture lag time of 2.09 hours, and profiles at 4, 20, 4...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2011-12-13 | E-GEOD-22294 | biostudies-arrayexpress
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