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TranscriptomicsExperimental identification of small non-coding RNAs in the model marine bacterium Ruegeria pomeroyi DSS-3
In oligotrophic ocean waters where bacteria are often subjected to chronic nutrient limitation, community transcriptome sequencing has pointed to the presence of highly abundant small RNAs (sRNAs). The role of sRNAs in regulating response to nutrient stress was investigated in a model heterotrophic ...
ORGANISM(S): Ruegeria pomeroyi DSS-3 
2016-02-27 | E-MTAB-4468 | biostudies-arrayexpress
ModelsChan2004_TCell_receptor_activation
The model reproduces Fig 3a of the paper. Please note that the authors mention that they used a value of 2 for n, n being the power in the positive feedback function for kinase autocatalysis, however the model here has n=1.95 because this results in a simulation that is identical to Fig 3a. The mode...
2024-09-02 | BIOMD0000000120 | BioModels
ProteomicsAn Approach to Measuring Protein Turnover in Human Induced Pluripotent Stem Cell Organoids by Mass Spectrometry
Patient-derived organoids from induced pluripotent stem cells have emerged as a model for studying human diseases beyond conventional two-dimensional (2D) cell culture. As such, the development of robust methods to study global proteostasis and protein turnover in organoids will remain essential as ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD032169 | Pride
Midbrain organoid Midbrain Silac Half-life determination Turnover D3-leucine Topograph Organoid 
TranscriptomicsTranscription profiling of human HCMV-Infected monocytes
Human cytomegalovirus induces a pro-inflammatory monocyte following infection and we have evidence that NF-κB and phosphatidylinositol 3-kinase [PI(3)K] are key mediators in this early activation. To begin to address how these signalling pathways are responsible for the rapid activation of infecte...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9601 | biostudies-arrayexpress
ProteomicsProteomic analysis of somatosensory cortex of Pten haploinsufficient mice
To discover differentially expressed proteins in somatosensory cortex of Pten haploinsufficient mice at adolescence (P30). Result reveals signatures of perturbation of dendritic spine development, keratinization and hamartoma. These are collectively respresentating molecular perturbation of neuropat...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-26 | PXD030573 | Pride
Q-exactive hf-x Pten Itraq Somatosensory cortex Lc-ms/ms 
MetabolomicsExamining the effects of cigarette smoke on mouse lens through a multi OMIC approach
Here, we report a multi OMIC (transcriptome, proteome, and metabolome) approach to investigate molecular changes in lens fiber cells (FC) of mice exposed to cigarette smoke (CS). Pregnant mice were placed in a whole-body smoke chamber and a few days later pups were born, which were exposed to CS for...
2024-03-24 | MTBLS207 | MetaboLights
TranscriptomicsRNA-seq transcriptomes of term not in labour and term in labour human myometrial tissue
Purpose: To chart the human myometrial transcriptomes before and after the onset of labour. Methods: Tophat splice junction mapping of paired-end reads, HTSeq to generate counts, cufflinks to track transcripts, DESeq, edgeR and baySeq to detect differentially expressed genes and principal component ...
ORGANISM(S): Homo sapiens 
2014-02-17 | E-GEOD-50599 | biostudies-arrayexpress
ProteomicsExamining the modality-dependent target specificity of bioPROTACs by analysing global proteome changes following mRNA-encoded or recombinant protein biodegrader delivery.
Proteolysis targeting chimeras (PROTACs) have surged in popularity as a drug modality owing to their ability to degrade pathogenic proteins. Despite their advantages over conventional inhibitors, PROTAC discovery still requires high-affinity warheads, but ligands for undruggable proteins are difficu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-27 | PXD049388 | Pride
Recombinant protein Proteomics Lipid nanoparticle Protac Gtpase Mass spectrometry Ras Drug delivery Bioprotac Mrna Cytosolic delivery Kras 
TranscriptomicsTranscription profiling of human HCMV-Infected monocytes study 2
Human cytomegalovirus induces a pro-inflammatory monocyte following infection. To begin to address how HCMV induces these rapid changes in infected monocytes, we examined the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed a significant number ...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-11408 | biostudies-arrayexpress
UnknownA Health Plan's Formulary Led To Reduced Use Of Extended-Release Opioids But Did Not Lower Overall Opioid Use.
Not available
S-EPMC6407123 | biostudies-literature
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