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TranscriptomicsExpression data for inbred mouse brains
Prion diseases are fatal neurodegenerative disorders that include bovine spongiform encephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans. They are characterized by long incubation periods, variation in which is determined by many factors including genetic backgro...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-38205 | biostudies-arrayexpress
ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - identification of ubiquitin-rbx1 crosslinks
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049047 | Pride
Ubiquitin Photocrosslinking Crl2vhl Rbx1 
TranscriptomicsExpression of lignin-degrading enzymes in soils using targeted microarrays
Microarrays have become established tools for describing microbial systems, however the assessment of expression profiles for environmental microbial communities still presents unique challenges. Notably, the concentration of particular transcripts are likely very dilute relative to the pool of tot...
ORGANISM(S): Phanerochaete chrysosporium 
2010-05-18 | E-GEOD-13977 | biostudies-arrayexpress
ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - verification of ubiquitin UBE2R1 (C93K) loading assay
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049050 | Pride
Structural Mimetic Ube2r1 Ubiquitin E2 
ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - identification of BRD4 ubiquitination sites
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049043 | Pride
Protac Mz1 Ubiquitin Crl2vhl Brd4 
UnknownEvaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600-mutant tumours.
Not available
S-EPMC5867134 | biostudies-literature
UnknownContinuous Versus 1-Year Fixed-Duration Nivolumab in Previously Treated Advanced Non-Small-Cell Lung Cancer: CheckMate 153.
Not available
S-EPMC7676888 | biostudies-literature
UnknownCorrelative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From BOLERO-2.
Not available
S-EPMC5070556 | biostudies-literature
UnknownDissecting the effect of mitochondrial BCAT inhibition in methylmalonic acidemia.
Not available
S-EPMC12487681 | biostudies-literature
UnknownPhase Ib study of combinations of avadomide (CC-122), CC-223, CC-292, and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma.
Not available
S-EPMC9176062 | biostudies-literature
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