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ProteomicsA 7-month e-vapor aerosol inhalation toxicology study in C57BL/6 mice [Lung data]
A 7-month inhalation study in C57BL/6 mice was conducted to evaluate long-term respiratory toxicity of e-vapor aerosols compared to cigarette smoke and to assess the impact of smoking cessation or switching to an e-vapor product after 3 months of exposure to 3R4F cigarette smoke (CS). In this study,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-31 | PXD019918 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsSystems toxicology assessment of CHTP1.2 [Lung Data]
Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxi...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-03-19 | PXD008422 | Pride
Rat Mrtp Itraq Lc-msms Systems toxicology 
ProteomicsSystems toxicology assessment of CHTP1.2 [Liver Data]
Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxi...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-03-19 | PXD008423 | Pride
Rat Mrtp Itraq Lc-msms Systems toxicology 
ProteomicsSystems toxicology assessment of CHTP1.2 [RNE Data]
Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxi...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-03-19 | PXD008424 | Pride
Rat Mrtp Itraq Lc-msms Systems toxicology 
ProteomicsInteraction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling
Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities including protein quality control, calcium flux, and sterol homeostasis. At least 25 different, transmembrane domain (TMD)-containing E3s are predicted to be ER-localised, but for most ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-06 | PXD019559 | Pride
Sting Innate immune response Ubiquitin ligase Endoplasmic reticulum Rnf26 
ProteomicsA FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency
The transcription factor FOXN1 is a master regulator of thymic epithelial cell development and function. Here we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in multi-molecular nuclear condensates essential for the factor's transcriptional activ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-29 | PXD025552 | Pride
Forkhead box n1 transcription factor Thymus Immunodeficiency 
TranscriptomicsA Supervised Risk Predictor of Breast Cancer Based on Biological Subtypes
Purpose: The biological subtypes of breast cancer designated as Luminal A, Luminal B, HER2+/ER-, and Basal-like are clinically important for prognosis and planning treatment strategies. Recognizing that there is a continuum in both the spectrum of breast cancer disease and the risk of survival, we s...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10886 | biostudies-arrayexpress
MetabolomicsNicotinamide Riboside is Uniquely Bioavailable in People and Mice
Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we conducted experiments to determine the time and dose-dependent effects of NR on blood, liver and heart NAD+ metabolism in people and mice. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single d...
2016-09-09 | MTBLS368 | MetaboLights
UnknownAntenatal care utilisation and receipt of its components in Nigeria: Assessing disparities between rural and urban areas-A nationwide population-based study.
Not available
S-EPMC11249263 | biostudies-literature
ProteomicsA quantitative label-free analysis of the extracellular proteome of human supraspinatus reveals damage to the pericellular and elastic fibre niches in torn and aged tendons
Tears of the human supraspinatus tendon are common and often cause painful and debilitating loss of function. Progressive failure of the tendon leading to structural abnormality and tearing is accompanied by numerous cellular and extra-cellular matrix (ECM) changes in the tendon tissue. This proteom...
ORGANISM(S): Homo sapiens (Human) 
2018-07-03 | PXD006466 | Pride
Human Label-free Supraspinatus 
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