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ProteomicsIdentification of Siglec-E-ligand candidates on BCL-1 mouse B cell line by proximity labeling
Siglec-E is a member of Siglec family of glycan recognition proteins involved in the regulation of myeloid cell activities. Siglec-E preferentially recognizes disialic acid, a glycan epitope consisting of two sialic acids conjugated in alpha2-8 linkage (Zhang JQ et al., Eur J Immunol. 2004, 34:1175...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-25 | PXD013032 | Pride
Lc-msms Siglec-e Mouse Ligand B cell Sialic acid 
MetabolomicsWhole blood metabolomics of dementia patients reveal classes of disease-linked metabolites

Dementia is caused by factors that damage neurons. We quantified small molecular markers in whole blood of dementia patients, using non-targeted liquid chromatography-mass spectroscopy (LC-MS). Thirty-three metabolites, classified into 5 groups (A-E), differed significantly in dementia patients, ...

2021-07-06 | MTBLS2109 | MetaboLights
ProteomicsEndogenous S-nitrosoproteome in colorectal cancer patients
Total lysate of tumorous and adjacent normal tissues from each colorectal cancer patient are followed by S-alkylating biotin switch strategy. All biotinylated peptides are analyzed by label-free quantitation and LC-MS/MS analysis. All peak lists from 66 raw MS/MS spectra were processed to mgf format...
ORGANISM(S): Homo sapiens (Human) 
2014-08-20 | PXD000467 | Pride
Tissue S-nitrosylation Biotin switch Human Colorectal cancer 
ProteomicsMouse Skin LC-MS/MS
Previously, we reported that a null mutation of the Zdhhc13 gene caused by ethylnitrosourea (ENU) mutagenesis in mice resulted in severe systematic phenotypes with amyloidosis, alopecia, dermatitis and osteoporosis. In this study we continued to delineate the pathological mechanism for the dermatiti...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-25 | PXD002958 | Pride
Mouse skin tissue Palmitoylation Lc-ms/ms 
ProteomicsSerpinB2/TPPII regulates senescence
Tripeptidyl peptidase II (TPPII) degrades N-terminal tripeptides from proteins and peptides. Studies in both human and mice have shown that TPPII deficiency is linked to cellular immune-senescence, lifespan regulation, and the aging process. However, the mechanism of how TPPII participates in these ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033808 | Pride
Activity-based probe  serine hydrolase  tpp  senescence  benzylphosphonofluoridate 
ProteomicsGlycoproteome of Human lung cancer cell by LC-MSMS
We demonstrate the utility of lectin-magnetic nanoprobe coupled with Orbitrap HCD-CID-MS/MS for complementary glycotope-specific enrichment and site-specific glycosylation analysis of the glycoproteome. Using non-small cell lung cancer (NSCLC) cells as model, this approach allowed us to compare the ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD010035 | Pride
Lc-msms Lung cancer cell Human Glycoproteom 
ProteomicsIdentification of Siglec-7-ligand candidates on JVM-3 human B cell line by proximity labeling
Siglec-7 is a member of Siglec family of glycan recognition proteins involved in the regulation of natural killer (NK) cell activities. We found Siglec-7 ligand is highly expressed on JVM-3, a B cell chronic lymphocytic leukemia (B-CLL) cell line. In this experiment, we attempted at identifying th...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD024690 | Pride
Human Lc-msms Siglec-7 Ligand B cell Sialic acid 
UnknownGlomerular injury induced by vinyl carbamate in A/J inbred mice: a novel model of membranoproliferative glomerulonephritis.
Not available
S-EPMC11412833 | biostudies-literature
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
UnknownDeciphering the Formulation Secret Underlying Chinese Huo-Clearing Herbal Drink.
Not available
S-EPMC8100228 | biostudies-literature
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