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ProteomicsTargeting Pim2 Improves Effector Function and Longevity of CD8 T cells in Cancer Immunotherapy
The Pim kinase family is critically involved in tumorigenesis, yet its function in primary T cells remains poorly understood. We previously reported that Pim2 negatively regulates T-cell responses to alloantigen. To investigate how Pim2 impacts anti-tumor immunity of CD8 T cells, we generated Pim2-/...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-08 | PXD059837 | Pride
Pim2 T cells Cancer Immunotherapy 
ProteomicsIntegrative Network Analysis Reveals USP7 Haploinsufficiency Inhibits E-protein Activity in Pediatric T-lineage Acute Lymphoblastic Leukemia (T-ALL)
USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of >200 T-ALL tran...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD023377 | Pride
Tal1 T-all Usp7 
UnknownA mobile app implementing the international classification of functioning, disability and health rehabilitation set.
Not available
S-EPMC6988202 | biostudies-literature
UnknownThe complete chloroplast genome sequence of Thunbergia erecta (Benth.) T. Anders. (Acanthaceae).
Not available
S-EPMC9677974 | biostudies-literature
UnknownD-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis.
Not available
S-EPMC8918796 | biostudies-literature
UnknownOptical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice.
Not available
S-EPMC9079778 | biostudies-literature
UnknownNanoparticle-Delivered siRNA Targeting NSUN4 Relieves Systemic Lupus Erythematosus through Declining Mitophagy-Mediated CD8+T Cell Exhaustion.
Not available
S-EPMC12318824 | biostudies-literature
ProteomicsProteome profiles in diabetic thoracic and abdominal aortas
This study provides a comprehensive atlas of how proteomic profiles are distinct in thoracic and abdominal aortas of spontaneously diabetic mice.
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD067688 | Pride
Aorta  diabetes mellitus  obesity  proteomic 
UnknownBispecific NK-cell engager targeting BCMA elicits stronger antitumor effects and produces less proinflammatory cytokines than T-cell engager.
Not available
S-EPMC10126364 | biostudies-literature
UnknownER stress sensor PERK promotes T cell pathogenicity in GVHD by regulating ER-associated degradation.
Not available
S-EPMC12646671 | biostudies-literature
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