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ProteomicsProteome Dynamics Underlying Drought Resistance Heterosis in Rice Flag Leaves
This study investigates the molecular mechanisms underlying drought resistance heterosis (DRH) in rice, specifically using the water-saving and drought-resistant rice hybrid Hanyou73 (HY73) and its parental lines Hanhui3 (HH3) and Huhan7B (HH7B). Given the significant impact of drought stress on glo...
ORGANISM(S): Oryza sativa (Rice) 
2026-06-28 | PXD064898 | Pride
Dia-ms Proteomic Flag leaf Heterosis Drought resistance Rice 
ProteomicsArsenic Trioxide Acts as a Molecular Glue to Promote STUB1-Mediated NPM-ALK Degradation in ALK⁺ ALCL
The NPM-ALK fusion constitutively activates ALK tyrosine kinase, driving oncogenesis in anaplastic large cell lymphoma (ALCL). Although arsenic trioxide (ATO) exhibits therapeutic potential in NPM-ALK⁺ ALCL by inhibiting proliferation and inducing apoptosis, its molecular mechanism remains unclear. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD074054 | Pride
Karpas299 Ato Targeted protein degradation Npm-alk+ alcl 
ProteomicsArsenic Trioxide Acts as a Molecular Glue to Promote STUB1-Mediated NPM-ALK Degradation in ALK⁺ ALCL
The NPM-ALK fusion constitutively activates ALK tyrosine kinase, driving oncogenesis in anaplastic large cell lymphoma (ALCL). Although arsenic trioxide (ATO) exhibits therapeutic potential in NPM-ALK⁺ ALCL by inhibiting proliferation and inducing apoptosis, its molecular mechanism remains unclear. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD073992 | Pride
Deslanoside Ato Targeted protein degradation Npm-alk+ alcl Stub1 Combination therapy 
ProteomicsPathogen protein modularity enables mimicry of a host phosphatase
Pathogens rely on a diverse complement of effector proteins to manipulate host cellular processes. The devastating plant pathogen Phytophthora produces numerous effectors that consist of tandem repeats of the “(L)WY” motif. Here, we discovered a specific (L)WY-LWY combination that enables efficient ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-10-01 | PXD034179 | Pride
Arabidopsis Effector Phosphatase Phytophthora 
ProteomicsDimeric Copper Peptide Incorporated Hydrogel for Promoting Diabetic Wound Healing
Diabetic wounds require continuous and coordinated modulation of the microenvironment concurrent with tissue regeneration, yet this remains a significant challenge. As a proof of concept, we herein propose to use dimeric copper peptide for diabetic wound treatment. The dimeric copper peptide (D-CuP)...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-11 | PXD059903 | Pride
Diabetic wound healing Dimeric copper peptide Ros-responsive hydrogels Continuous and coordinated modulation Deformability and spreadability 
ProteomicsLysine acetylomic profiling of hybrid rice HY73 in response to drought
This study investigates the molecular mechanisms underlying drought-resistant heterosis (DRH) in the elite hybrid rice HY73. Utilizing a quantitative lysine acetylome profiling approach on flag leaves of HY73 under well-watered (WW) and drought-stressed (DS) conditions, we aimed to unravel the role ...
ORGANISM(S): Oryza sativa (Rice) 
2026-06-28 | PXD064916 | Pride
Hybrid rice Drought resistance Lysine acetylation Acetylome Heterosis 
ProteomicsEvaluation And Characterization Of Acute Respiratory Distress Syndrome In Tree Shrews Through TMT Proteomic Method
Acute respiratory distress syndrome (ARDS), a common cause of acute fatal respiratory, is characterized by severe inflammatory lung injury as well as hallmarks of increased pulmonary vascular permeability, neutrophil infiltration, and macrophage accumulation. Tree shrew, a squirrel-like small animal...
ORGANISM(S): Tupaia chinensis 
2025-05-07 | PXD053328 | Pride
Acute respiratory distress syndrome  tree shrew  tmt proteomics  lungs  immunological responses 
ProteomicsIn situ delivery of immune-synapse-stabilizing NK cells for postoperative tumor intervention
Natural killer (NK) cells eliminate target cells by forming an immunological synapse (IS). This process, however, is frequently thwarted by their “kiss-and-run” behavior characterized by transient, abortive interactions. Here, we equip NK cell with multivalent ligands that resemble prehensile “arms”...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-26 | PXD073114 | Pride
Natural killer cells Immune synapse Spatiotemporal delivery Multivalent interaction Postoperative tumor intervention 
ProteomicsProteomic sequencing of Giardia duodenalis-secreted extracellular vesicles
The study involved the proteomic sequencing of extracellular vesicles secreted by Giardia duodenalis, statistical analysis of detected proteins, and GO analysis and enrichment KEGG analysis of proteins
ORGANISM(S): Giardia intestinalis (Giardia lamblia) 
2025-05-07 | PXD054439 | Pride
Giardia duodenalis  extracellular vesicles  lc-msms 
ProteomicsIdentification of DDR1-interacting proteins by IP-MS screening
To investigate and identify the potential DUBs that stabilize and interact with DDR1, we performed immunoprecipitation of endogenous DDR1 with anti-DDR1 antibody (specific IP) or anti-IgG antibody (negative control) in A549 cells followed by mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD065332 | Pride
Ddr1 Ip-ms Co-immunoprecipitated proteins 
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