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ProteomicsMapping PP1c and its Inhibitor 2 interactomes reveals conserved and specific networks in asexual and sexual stages of Plasmodium
Malaria parasites require multiple phosphorylation and dephosphorylation steps to drive signaling pathways for proper differentiation and transformation. Several protein phosphatases, including Protein Phosphatase 1 (PP1c), one of the main dephosphorylation enzymes, have been shown to be indispensab...
ORGANISM(S): Mus musculus (Mouse) Plasmodium berghei ANKA 
2022-02-22 | PXD029283 | Pride
Dephosphorylation Inhibitor 2 Interactomics Interactome Pp1 partners. Protein phosphatase 1 Plasmodium 
ProteomicsA sensitive S-trap-based approach to the analysis of T-cell raft proteome
The development of sensitive technologies for T cell-raft proteomics is highly challenging. We explored an innovative strategy, based on suspension trapping (S-trap) sample preparation. Mouse splenocytes were subjected to negative immunoselection for T cell preparation. Rafts were isolated by a dete...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-13 | PXD016476 | Pride
T cell Optiprep Raftomics Fasp S-trap Detergent-free 
ProteomicsOenothera effect on senescent NDHF
Accumulation of senescent dermal fibroblasts drives skin aging, impairing the integrity of the extracellular matrix (ECM) and the function of neighbouring cells. One of strategies to manipulate cell senescence include the reactivation of proliferation. Here, a data independent mass spectrometry base...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034222 | Pride
Hydrophilic extract of oenothera biennis cell cultures  senescence  proteomics  data independent mass spectrometry  fibroblasts 
ProteomicsThe Pentose Phosphate Pathway in pathogenic Francisella
Metabolic pathways are now considered as intrinsic virulence attributes of pathogenic bacteria and hence represent potential targets for anti-bacterial strategies. Here, we addressed the role of the pentose phosphate pathway (PPP) and its connections with other metabolic pathways in the pathophysiol...
ORGANISM(S): Francisella tularensis subsp. novicida 
2021-07-27 | PXD023550 | Pride
Francisella tularensis. Intracellular parasitism Metabolic adaptation Pentose phosphate pathway 
ProteomicsSickle cell trait modulates the proteome and phosphoproteome of Plasmodium falciparum-infected erythrocyte
The high prevalence of sickle cell disease in some human populations likely results from the protection afforded against severe Plasmodium falciparum malaria and death by heterozygous carriage of HbS. P. falciparum remodels the erythrocyte membrane and skeleton, displaying parasite proteins at the e...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2021-04-19 | PXD023280 | Pride
Plasmodium falciparum Membrane phosphorylation Erythrocyte Hemoglobin s Proteomics. 
ProteomicsPhosphoproteome analysis of TgPP1 depleted Toxoplasma gondii tachyzoites
Virulence of apicomplexan parasites is based on their ability to divide rapidly to produce significant biomass. The regulation of their cell-cycle is therefore key to their pathogenesis. Phosphorylation is a crucial post-transcriptional modification that regulates many aspects of the cell cycle. Th...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii GT1 
2024-08-08 | PXD043539 | Pride
Phosphorylation Phosphoproteome Toxoplasma Parasites Lc-ms/ms 
ProteomicsProteomics of plasma and plasma-treated podocytes: application to focal and segmental glomerulosclerosis
Focal and segmental glomerulosclerosis (FSGS) is a severe form of idiopathic nephrotic syn-drome (INS), a glomerulopathy of presumable immune origin and attributed to extrarenal path-ogenic circulating factors. FSGS recurrence (rFSGS) after transplant occurs in 30 to 50% of cases. Direct analysis of...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042379 | Pride
Plasma Immunodepletion Extracellular vesicles Raftomics Phosphoproteomics 
ProteomicsPlasmodium berghei Leucin Rich Repeat 1 involvement in early sporogony
Phosphatase type 1 is a major enzyme essential to Plasmodium development. However, the detailed mechanisms underlying its regulation remain to be deciphered. In this work, we report the functional characterization of the Plasmodium berghei LRR1, an ortholog of SDS22, one of the most ancient and cons...
ORGANISM(S): Plasmodium berghei ANKA 
2022-10-14 | PXD030389 | Pride
Plasmodium berghei Immunoprecipitation Q-exactive plus Lc-ms/ms 
ProteomicsDual proteomics of infected macrophages identifies potential novel players involved in Francisella cell to cell dissemination
dual proteomics, merocytophagy, intracellular parasitism, Francisella tularensis
ORGANISM(S): Mus musculus (Mouse) Francisella tularensis subsp. novicida (strain U112) 
2024-03-29 | PXD035145 | Pride
Merocytophagy Francisella tularensis Dual proteomics Intracellular parasitism 
ProteomicsIntegrative cell type-specific multi-omics approaches reveal impaired programs of glial cell differentiation in mouse culture models of DM1
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by a non-coding CTG repeat expansion in the DMPK gene. This mutation generates a toxic CUG RNA that interferes with the RNA processing of target genes in multiple tissues. Despite debilitating neurological impairment, the pathophysio...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-26 | PXD025011 | Pride
Myotonic dystrophy Astrocytes Ontology Neurons Multi-omics Splicing Transcriptomics Phosphoproteomics Oligodendrocytes Lc-ms/ms 
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