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MetabolomicsOptimizing Deconvolution of Chimeric Fragmentation Spectra to reveal molecular structures of complex biological mixtures

Direct infusion mass spectrometry (DI-MS) offers a rapid, high-throughput analysis and, compared to liquid chromatography MS (LC-MS), a different analytical window into the composition of complex biological samples. However, the lack of chromatographic separation in DI-MS results in highly comple...

MTBLS13066 | MetaboLights
MetabolomicsImproving Metabolite Identification with DecoID for Database-Assisted Deconvolution of Metabolomic MS/MS Spectra

Chimeric MS/MS spectra contain fragments from multiple precursor ions and therefore hinder compound identification in metabolomics. Historically, deconvolution of these chimeric spectra has been challenging and relied upon specific experimental methods that introduce variation in the ratios of pr...

2021-04-29 | MTBLS2207 | MetaboLights
ProteomicsCharmeRT - CharmeRT: Boosting peptide identifications by chimeric spectra identification and retention time prediction
Files include several HeLa tryptic digests with different isolation widths and different gradient times for chimeric spectra identification and validation, each of them as three technical replicates
ORGANISM(S): Homo sapiens (Human) 
2018-06-12 | PXD007750 | Pride
Chimeric spectra Hela Lc-msms 
ProteomicsCharmeRT - CharmeRT: Boosting peptide identifications by chimeric spectra identification and retention time prediction
Files include several HeLa tryptic digests with different isolation widths and different gradient times for chimeric spectra identification and validation, each of them as three technical replicates
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-09 | MSV000089624 | MassIVE
ProteomicsAn updated perspective on deconvoluting chimeric MS/MS spectra by LC and precursor isolation and their subsequent assignment by the CharmeRT mPSM search strategy
Considering the recent advances in LC and mPSM methodologies, we aimed to provide a systematic comparison and in-depth analysis of the effects that standard and specialized LC setups, as well as different isolation windows, have on the occurrence and assignment of chimeric spectra derived from a com...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012635 | Pride
Liquid chromatography Tandem mass spectrometry Chimeric spectra Isolation interference 
ProteomicsChimeric design of Pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion
An orthogonal aminoacyl-tRNA synthetase/tRNA pair is a key prerequisite for site-specific incorporation of unnatural amino acids. Due to its high codon suppression efficiency and full orthogonality, the pyrrolysyl-tRNA synthetase/pyrrolysyl-tRNA pair is currently the ideal system for genetic code ex...
ORGANISM(S): Escherichia coli 
2020-05-25 | PXD018660 | Pride
Chimeric design Genetic code expansion 
ProteomicsComparative transcriptomic and proteomic analyses reveal multiple differences associated with albino leaves in Ananas comosus var. Bracteatus
Ananas comosus var. bracteatus has high ornamental value and widespread application because of its chimeric leaves. However, little is known about the molecular mechanism regulating this characteristic. Here, comparative transcriptomic and proteomic analyses of the white parts (Whs) and green parts ...
ORGANISM(S): Ananas comosus var. bracteatus 
2019-06-10 | PXD010375 | Pride
Molecular mechanism Chimeric leaves Proteome Ananas comosus var. bracteatus Transcriptome 
UnknownreSpect: software for identification of high and low abundance ion species in chimeric tandem mass spectra.
Not available
S-EPMC4750398 | biostudies-literature
ProteomicsAn Informatic Approach to Chimeric Antigen Receptor Discovery Integrates Proteomics and Transcriptomics to Identify Novel Combinatorial Pairs
Chimeric antigen receptor (CAR) therapy targeting CD19 yielded remarkable outcomes in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute myeloid leukemia (AML), we probed the AML surfaceome for over-expressed molecules with potentially tolerable systemic expressio...
ORGANISM(S): Homo sapiens (Human) 
2017-10-24 | PXD007552 | Pride
Tf Thpi Monomac Kasumi Human aml cell lines lc-msms Molm13 09aml 
ProteomicsComparative quantitative proteomic analysis of Chlamydomonas reinhardtii cells from wild-type and chimeric FNR-PSAF mutant cells
Photosynthetic linear electron transfer (LET) comprises a solar energy driven pathway tha directs electrons to the production of NADPH, via ferredoxin-NADP+ reductase (FNR), while generating a proton motive force (pmf) to drive ATP synthesis. Both NADPH and ATP are consumed for carbon fixation. Howe...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-05-07 | PXD052753 | Pride
Chloroplast Cyclic electron transfer Crispr-cas9 Photosystem (ps) Let Ferredoxin-nadp+ reductase Chlamydomonas reinhardtii Psi subunit psaf Linear electron transfer Cet 
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