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MetabolomicsIDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

Metabolic reprogramming under therapeutic stress may represent a targetable vulnerability for cancer treatment. Elucidation of the metabolic alterations linked to chemotherapy in nasopharyngeal carcinoma (NPC) could uncover potential therapeutic strategies. Using proteomics and transcriptomic pro...

2026-01-14 | MTBLS11531 | MetaboLights
ProteomicsReduced polymerase pausing compensates for increased chromatin accessibility in the aging liver
Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile. However, little is known about the changes on the level of transcriptional regulation. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-15 | PXD034564 | Pride
Tmt Chromating Polymerase Liver Aging 
TranscriptomicsChromatin Accessibility Reveals Insight into Androgen Receptor Activation and Transcriptional Specificity
Using DNase-seq, mRNA-seq and publicly available ChIP-seq data sets, we examined the role of chromatin accessibility (DNase-seq) in androgen receptor binding to the genome (ChIP-seq) and AR-mediated transcriptional changes (mRNA-seq). Our data reveals genome-wide changes in chromatin structure that ...
ORGANISM(S): Homo sapiens 
2012-08-14 | E-GEOD-34780 | biostudies-arrayexpress
GenomicsIdentification of chromatin accessibility domains in EMT and breast cancer stem cell formation.
Epithelial-mesenchymal transition (EMT), the process whereby cells gain migratory and invasive properties characteristic of mesenchymal cells, plays a central role in embryogenesis and wound healing in a wide range of tissues. However, EMT has also been linked to the formation of cancer stem cells (...
ORGANISM(S): Homo sapiens 
2016-03-10 | E-GEOD-71023 | biostudies-arrayexpress
GenomicsRapid Genome-Scale Mapping of Chromatin Accessibility in Tissue
Here we introduce a novel technique that specifically identifies Tissue Accessible Chromatin (TACh). The TACh method uses pulverized frozen tissue as starting material and employs one of the two robust endonucleases, Benzonase or Cyansase, which are fully active under a range of stringent conditions...
ORGANISM(S): Mus musculus 
2012-08-10 | E-GEOD-39982 | biostudies-arrayexpress
GenomicsTE-associated chromatin variation in mice livers
Chromatin accessibility is a hallmark of active regulatory function in the genome and variation of chromatin accessibility across individuals has been shown to contribute to complex traits and disease susceptibility. However, the mechanisms responsible for chromatin variation among different individ...
ORGANISM(S): Mus musculus 
2016-07-14 | E-GEOD-75770 | biostudies-arrayexpress
ProteomicsSUMOylation regulates chromatin protein network and accessibility at glucocorticoid receptor-binding sites
Glucocorticoid receptor (GR) is an essential transcription factor (TF), controlling metabolism, development and immune responses. SUMOylation regulates chromatin occupancy and target gene expression of GR in a locus-selective manner, but the mechanism of regulation has remained elusive. Here, we sho...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015183 | Pride
Glucocorticoid receptor Proteomics Chromatin regulation Sumoylation Transcription factors 
ProteomicsID3 Deficiency Alters Chromatin Accessibility at DSB Sites and Enhances Vulnerability to HDAC Inhibition
The inhibitor of DNA-binding 3 (ID3) plays a crucial role in DNA double-strand break (DSB) repair. We previously reported that ID3 loss reduced chromatin accessibility at DNA repair gene promoters, yet its exact role in DNA repair via chromatin regulation remained elusive. Using the AID-DIvA cell sy...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD069605 | Pride
Id3 Chromatin accessibility Hdac Dsb Inhibition 
GenomicsDNA accessibility profile of three C. elegans tissues during development
We show there is minimal genome-wide chromatin rearrangements (as measured by DNA accessibility) during tissue differentiation in C. elegans transgenic expression of E. coli DAM (DNA Adenine Methyltransferase) from tissue-specific promoters followed by mapping of methylated sites using a procedure t...
ORGANISM(S): Caenorhabditis elegans 
2011-04-16 | E-GEOD-23042 | biostudies-arrayexpress
GenomicsChromatin accessibility maps of chronic lymphocytic leukemia identify subtype-specific epigenome signatures and transcription regulatory networks
Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ...
ORGANISM(S): Homo sapiens 
2016-06-26 | E-GEOD-81274 | biostudies-arrayexpress
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