Chromosome segregation

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Bacillus subtilis subsp. subtilis str. 168 (4)
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synthetic construct (3)
Streptomyces venezuelae (3)
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Eucalyptus grandis x Eucalyptus urophylla (2)
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Organisms

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unidentified (3)
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Caulobacter vibrioides NA1000 (2)
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Chlamydomonas reinhardtii (2)
Borreliella burgdorferi (2)
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Bacillus subtilis subsp. subtilis str. 168 (2)
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Myxococcus xanthus DK 1622 (1)

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Illumina MiSeq, Illumina HiSeq 2500 (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (12)
Illumina HiSeq 2500 (6)
Illumina HiSeq 2000 (5)
Illumina HiSeq 4000 (4)
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Q Exactive Plus (4)
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FACS BD Aria II & III (1)
10X v3 (1)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (1)
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Illumina Human-12 v1 Expreesion BeadChip (1)
Axon- GenePix4000B (1)
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Ion Torrent S5 XL (1)
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Publication Date

2013 (340)
2010 (209)
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2011 (85)
2015 (63)
2020 (62)
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2014 (47)
2022 (38)
2019 (38)
2017 (38)
2016 (35)
2018 (31)
2023 (24)
2009 (21)
2008 (12)
2007 (10)
2005 (9)
2006 (5)

UNIPROT ID/AC

Q00362 (2)
P32562 (2)
P38987 (2)
P40316 (2)
P47035 (2)
Q03018 (2)
P53197 (2)
P26309 (2)
P27636 (2)
Q00684 (2)
P24869 (2)
P01097 (1)
O60566 (1)
O43684 (1)
Q12834 (1)
Q13257 (1)
Q9Y6D9 (1)
P00546 (1)

CHEBI ID

CHEBI:141139 (2)
CHEBI:147305 (2)
CHEBI:50128 (2)
CHEBI:520 (2)
CHEBI:26847 (2)
CHEBI:16860 (2)
CHEBI:17521 (2)
CHEBI:16112 (2)
CHEBI:36062 (2)
CHEBI:33704 (1)
CHEBI:147316 (1)
CHEBI:147315 (1)
CHEBI:146138 (1)
CHEBI:137451 (1)
CHEBI:137448 (1)
CHEBI:50593 (1)
CHEBI:76698 (1)
CHEBI:137452 (1)
CHEBI:137453 (1)
CHEBI:65751 (1)
CHEBI:40813 (1)
CHEBI:52972 (1)
CHEBI:16933 (1)
CHEBI:137450 (1)
CHEBI:85153 (1)
CHEBI:50591 (1)
CHEBI:147329 (1)
CHEBI:147328 (1)
CHEBI:147327 (1)
CHEBI:5995 (1)

Metabolite Name

2,4,5-tricaffeoylaltraric acid (2)
2,3,5-tricaffeoylaltraric acid (2)
Protocatechuic acid (2)
Biflavonoid (2)
1,5-dicaffeoylquinic acid (2)
Altraric acid (2)
3-O-methylquercetin (2)
Quinic acid (2)
5-hydroxyanthraquinone-1,3-dicarboxylic acid (1)
Methyl 3-O-caffeoyl-4-O-feruloylquinate (1)
3,5-dicaffeoylquinic acid (1)
2-formyl tetrahydropyran-3-yl acetate (1)
Hydroxy-ent-kauren-18-oic acid (1)
Quercetin-3-O-methylpentoside-hexoside (1)
Di-methylquercetin (1)
PE(12:0/16:0) (1)
Ergosta-5,7,24(28)-trien-3beta-ol (1)
(2S,3S,4R)-2-aminohexadecane-1,3,4-triol (1)
3-dehydro-4-methylzymosterol (1)
Ergosterol (1)
Palmitoleic acid (1)
5-caffeoylquinic acid (1)
Xylonic acid isomers (1)
Xylonic acid (1)
Tricaffeoylaltraric acid (1)
3,4-dicaffeoylquinic acid (1)
1,3-dicaffeoylquinic acid (1)
Diacetyl altraric acid (1)
Dimethoxyflavonoid (1)
Isoetin (1)

First Public Date

2014 (81)
2024 (77)
2025 (75)
2021 (58)
2026 (57)
2020 (53)
2019 (45)
2017 (38)
2022 (36)
2023 (33)
2018 (29)
2016 (27)
2013 (27)
2015 (25)

Modelling Approach

Ordinary differential equation model (3)
Boolean model (1)

Lab affiliation

Chromosome Segregation Laboratory The Francis Crick Institute Midland Road London NW1 1AT (6)
Department of Biochemistry, University of Oxford (6)
Functional Proteomics, ICR (5)
University of Edinburgh (5)
Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth (3)
The University of Edinburgh (3)
1. Department I of Internal Medicine, Center for Integrated Oncology (CIO), Aachen-Bonn- Cologne-Duesseldorf, Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne (UoC), 50937 Cologne, Germany 2. Department of Hematology and Cellular Therapy, University of Leipzig, Leipzig, Germany (2)
Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK. (2)
Chromosome and Plasmid Segregation Lab, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India (2)
Department of Biochemsitry, University of Oxford (2)
Gene Center Munich and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany (2)
Head of the Curie Institute Mass Spectrometry Platform (2)
Integrative Parasitology, Centre for Infectious Diseases, University Hospital Heidelberg, Heidelberg University Medical Faculty; Heidelberg, Germany (2)
Proteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic (2)
Proteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark (2)
School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH (2)
University of Oxford (2)
West China Second University Hospital, Sichuan University (2)
Yale Cancer Biology Institute (2)
1 Max Planck Fellow Group Molecular Physiology of Microbes, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany 2 Center for Synthetic Microbiology (SYNMIKRO), Marburg, Germany 3 Department of Chemistry, University of Marburg, Marburg, Germany (1)
Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), Turing Center for Living Systems, Marseille, France (1)
Analytics Core Facility Essen (ACE), Chemische Biologie, Universität Duisburg-Essen, ZMB, Germany (1)
Andalusian Center for Moelcular Biology and Regenerative Medicine (CABIMER), University of Sevilla, Spain (1)
Anders H. Lund Professor, PhD Biotech Research and Innovation Centre University of Copenhagen Ole Maaloes Vej 5 DK-2200 N Copenhagen Denmark (1)
Associate Professor in Chromosome Dynamics and Stability (Genome Damage and Stability) Chromosome Dynamics and Stability Group Genome Damage and Stability Centre University of Sussex Brighton BN1 9RQ (1)
Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Germany (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands Netherlands Proteomics Centre, Utrecht, The Netherlands. (1)
CABIMER-University of Sevilla (1)
CNIO (1)
CRG/UPF (1)

IsPrivate

False (4)

Classification

bacteria (23)
protozoa (6)
fungi (4)
helminths (2)

Modification

-17.026549 (1)
15.994915 (1)
3x(2)H labeled N6-acetyl-L-lysine (1)
42.010565 (1)
47.036105 (1)
58.005479 (1)

Study type

ChIP-seq (206)
ChIP-chip by tiling array (135)
Transcription profiling by array (94)
RNA-seq of coding RNA (27)
Other (13)
Unknown experiment type (12)
Comparative genomic hybridization by array (11)
Genotyping by array (9)
RNA-seq of coding RNA from single cells (8)
ChIP-chip by array (7)
DNA-seq (5)
RNA-seq of non coding RNA (4)
Transcription profiling by tiling array (3)
Methylation profiling by high throughput sequencing (3)
Animal - High-throughput sequencing (2)
Cell line - High-throughput sequencing (2)
ATAC-seq (2)
MNase-seq (1)
RNA-seq of non coding RNA from single cells (1)
Cell line - One-color microarray (1)
RNAi profiling by array (1)
Hi-C (1)
Single nucleus RNA sequencing (1)
Methylation profiling by array (1)
CUT&RUN (1)
RNA-seq of total RNA (1)

Release Date

2013 (354)
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2019 (291)
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2011 (177)
2009 (113)
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2008 (78)
2007 (74)
2005 (61)
2026 (56)
2004 (28)
2003 (26)
2001 (22)
2002 (21)
2000 (16)
1998 (14)
1999 (11)
1997 (9)

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Deep functional analysis of synII, a 770 kb synthetic yeast chromosome

Here we report the design, construction and characterization of a 770 Kb synthetic yeast chromosome II (synII). With the UPLC-MS method, we demonstrated synII maintains a nearly wild-type phenotype and fitness despite hundreds of designer editing to it. Our phenomics, transcriptomics, proteomics dat...

2016-10-13 | MTBLS296 | MetaboLights

Chromosome segregation in Streptococcus pneumoniae

Segregation of replicated chromosomes during cell division is an essential process in all organisms. Chromosome segregation is promoted by the action of the DNA-binding ParB protein in the rod-shaped model bacterium Bacillus subtilis. How oval shaped bacteria, such as the human pathogen Streptococcu...

ORGANISM(S): Streptococcus pneumoniae

2011-06-11 | E-GEOD-26839 | biostudies-arrayexpress

Screening of genes involved in chromosome segregation in meiosis I

Prophase I of male meiosis involves dynamic chromosome segregation processes during early spermatogenesis, including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes r...

ORGANISM(S): Mus musculus

2010-03-31 | E-GEOD-19532 | biostudies-arrayexpress

Screening of genes involved in chromosome segregation in meiosis I

Prophase I of meiosis involves dynamic chromosome segregation processes including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility or recur...

ORGANISM(S): Mus musculus

2012-06-03 | E-GEOD-35734 | biostudies-arrayexpress

Metabolomic evidence for biogeographic segregation in Espeletiinae (Asteraceae): A new perspective on an Andean adaptive radiation in sky islands (Intraspecific chemical variability assay)

The biogeography of tropical Andean plants and the effects of altitudinal barriers as evolutionary constraints have been the focus of great debate. Although genetic markers have provided evidence for the geographic isolation of Andean-endemic groups, even highly variable molecular markers commonl...

2020-03-24 | MTBLS943 | MetaboLights

Metabolomic evidence for biogeographic segregation in Espeletiinae (Asteraceae): A new perspective on an Andean adaptive radiation in sky islands (Interspecific chemical variability assay)

2020-03-24 | MTBLS944 | MetaboLights

Mitotic chromosome scaffold

Quantitative proteomics analysis of mitotic chromosome scaffold based on SILAC

ORGANISM(S): Gallus Gallus

2018-10-07 | PXD007269 | JPOST Repository

Reductional meiosis I chromosome segregation is established by coordination of key meiotic kinases

Meiosis produces gametes through a specialised, two-step cell division, which is highly error-prone in humans. Reductional meiosis I, where maternal and paternal chromosomes (homologs) segregate, is followed by equational meiosis II, where sister chromatids separate. Uniquely during meiosis I, siste...

ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast)

2019-11-13 | PXD012627 | Pride

Genes required for aerial growth, cell division, and chromosome segregation are targets of WhiA before sporulation in Streptomyces venezuelae.

WhiA is a highly unusual transcriptional regulator related to a family of eukaryotic homing endonucleases. WhiA is required for sporulation in the filamentous bacterium Streptomyces, but WhiA homologues of unknown function are also found throughout the Gram-positive bacteria. To better understand th...

ORGANISM(S): Streptomyces venezuelae

2016-05-20 | E-MTAB-4673 | biostudies-arrayexpress

mitotic chromosome scaffold SMC2ON vs OFF

Quantitative proteomics analysis of mitotic chromosome scaffold based on SILAC

ORGANISM(S): Gallus Gallus

2018-10-07 | PXD008429 | JPOST Repository

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