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ProteomicsThe proteome of normal human iris, ciliary body, retinal pigment epithelium, and choroid
The iris is a fine structure that controls the amount of light that enters the eye. The ciliary body controls the shape of the lens and produces aqueous humor. The retinal pigment epithelium and choroid (RPE/choroid) are essential in supporting the retina and absorbing light energy that enters the e...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-29 | MSV000081766 | MassIVE
TranscriptomicsGene expression of the pigmented and non-pigmented epithelia of the ciliary body of human healthy eyes
The ciliary body (CB) of the human eye consists of the non-pigmented (NPE) and pigmented (PE) neuro-epithelia. We investigated the gene expression of the NPE and PE, to shed light on the molecular mechanisms underlying the most important functions of the CB. Therefore we isolated NPE and PE cells fr...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-37957 | biostudies-arrayexpress
ProteomicsA WDR35-dependent coatomer transports ciliary membrane proteins from the Golgi to the cilia
Intraflagellar transport (IFT) is a highly conserved mechanism for motor-driven transport of cargo inside cilia. However, the mechanism of selective transport of cargo to cilia and entry across the diffusion barrier is not well understood. WDR35/IFT121 is a component of the IFT-A complex, best known...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-03 | PXD022652 | Pride
Wdr35 Ciliary membrane Cilia Ifta 
TranscriptomicsGenome-wide gene expression analysis in primary ciliary dyskinesia patients
We performed whole genome gene expression profiling in bronchial biopsies from PCD patients. We used the Quality Threshold clustering algorithm to identify groups of genes that revealed highly correlated RNA expression patterns in the biopsies. The largest cluster contained 372 genes and was signifi...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-25186 | biostudies-arrayexpress
TranscriptomicsCiliary neurotrophic factor induces genes associated with inflammatory response and gliosis in the retina: A gene profiling study of flow-sorted, Muller (glial) cells
Our data suggest that CNTF remodels the transcription profile of Muller (glial) cells leading to induction of networks associated with transcription, cell cycle regulation and inflammatory response. CNTF also appears to function as an inducer of gliosis in the retina. These studies provide new insig...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-27195 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse T cell response to ocular pigment epithelial cells - role of thrombospondin 1
Ocular pigment epithelium (PE) cells promote the generation of T regulators (PE-induced Treg cells). Moreover, T cells exposed to PE acquire the capacity to suppress the activation of bystander T cells via TGFbeta. Membrane-bound TGFbeta on iris PE cells interacts with TGFbeta receptors on T cells, ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5134 | biostudies-arrayexpress
ProteomicsChlamydomonas reinhardtii ciliary membrane proteome
The cell membrane fraction of Chlamydomonas cw15 and the ciliary membrane fraction of Chlamydomonas cc125 were extracted by aqueous two-phase extraction and sucrose density gradient centrifugation, respectively. The membrane fractions were dissolved in 8 M urea to obtain plasma membrane proteins (PM...
ORGANISM(S): Chlamydomonas Reinhardtii 
2026-04-26 | PXD077643 |
UnknownRab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
Not available
S-EPMC8282722 | biostudies-literature
UnknownInteraction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.
Not available
S-EPMC7860134 | biostudies-literature
GenomicsCiliary associated extracellular vesicles modulate WNT signalling
Ciliary associated extracellular vesicles modulate WNT signalling
PRJNA641812 | ENA
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