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ProteomicsThe polyamine-hypusine circuit controls an oncogenic translational program necessary for MYC-driven lymphomagenesis
MYC oncogenes are activated in broad spectrum of human malignancies and transcriptionally reprogram the genome to drive cancer cell growth. Given this it is unclear if targeting a single effector will have a therapeutic benefit. MYC activates the polyaminehypusine circuit, which post-translationally...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD031361 | Pride
Tumorigenesis Lymphoma Eif5a Dhps Myc Polyamine-hypusine Translation 
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [Lymphoma].
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37790 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state
This SuperSeries is composed of the following subset Series: GSE33474: Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [bone marrow B cells]. GSE37790: Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37792 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [retrovirally infected ex vivo lymphoma]
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37791 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [bone marrow B cells].
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-33474 | biostudies-arrayexpress
TranscriptomicsGene Expression profiling of Myc-induced lymphomagenesis
The ability of oncogenes to provoke cancer is harnessed by regulators that control cell proliferation or induce apoptosis, and bypass of these checkpoints is a hallmark of malignancies. Myc oncoproteins are overexpressed in ~70% of all cancers and induce numerous transcription targets that regulate ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32239 | biostudies-arrayexpress
UnknownPhase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression.
Not available
S-EPMC3157965 | biostudies-literature
UnknownDNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient.
Not available
S-EPMC4830205 | biostudies-literature
UnknownPsychometric approaches to defining cognitive phenotypes in the Old Order Amish.
Not available
S-EPMC12000893 | biostudies-literature
UnknownMonocyte inflammation and resilience to Alzheimer's disease: novel genetic risk genes identified by transcriptome-wide association study.
Not available
S-EPMC12627486 | biostudies-literature
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