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ProteomicsThe polyamine-hypusine circuit controls an oncogenic translational program necessary for MYC-driven lymphomagenesis
MYC oncogenes are activated in broad spectrum of human malignancies and transcriptionally reprogram the genome to drive cancer cell growth. Given this it is unclear if targeting a single effector will have a therapeutic benefit. MYC activates the polyaminehypusine circuit, which post-translationally...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD031361 | Pride
Tumorigenesis Lymphoma Eif5a Dhps Myc Polyamine-hypusine Translation 
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [Lymphoma].
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37790 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state
This SuperSeries is composed of the following subset Series: GSE33474: Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [bone marrow B cells]. GSE37790: Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37792 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [retrovirally infected ex vivo lymphoma]
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37791 | biostudies-arrayexpress
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [bone marrow B cells].
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-33474 | biostudies-arrayexpress
TranscriptomicsGene Expression profiling of Myc-induced lymphomagenesis
The ability of oncogenes to provoke cancer is harnessed by regulators that control cell proliferation or induce apoptosis, and bypass of these checkpoints is a hallmark of malignancies. Myc oncoproteins are overexpressed in ~70% of all cancers and induce numerous transcription targets that regulate ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32239 | biostudies-arrayexpress
UnknownPhase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression.
Not available
S-EPMC3157965 | biostudies-literature
UnknownDNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient.
Not available
S-EPMC4830205 | biostudies-literature
ProteomicsUnc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma
Despite the availability of effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. To identify new therapeutic targets, we assessed RNA sequencing data from CD138+ MM patient cells (n = 813) across disease stages and found that an autophagy...
ORGANISM(S): Homo sapiens (Human) 
2026-05-27 | PXD067362 | Pride
Autophagy Ulk3 Interactome Multiple myeloma 
UnknownPsychometric approaches to defining cognitive phenotypes in the Old Order Amish.
Not available
S-EPMC12000893 | biostudies-literature
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