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ProteomicsPathogenic leptospires modulate protein expression and post-translational modifications in response to mammalian host signals
A large body of work has demonstrated that leptospires regulate and modify gene expression in response to environmental cues, as encountered during disease transmission, including changes in temperature, osmolarity, concentration of iron, the presence of serum, and interaction with macrophages. Howe...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2017-08-31 | PXD006995 | Pride
Dige Proteomics Post-translational modifications Spirochetes Leptospira 
ProteomicsAPE1 (apurinic/apyrimidinic endonuclease 1): newly identified post-translational modifications (PTMs)
APE1 (apurinic/apyrimidinic endonuclease 1) is a multifunctional protein essential for both DNA base excision repair and redox signaling. However, its post-translational modifications (PTMs), which are key to modulating its cellular functions, remain largely uncharacterized due to their dynamic and ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD067266 | Pride
Ptms Ape1 Live-cell Lc-ms/ms 
ProteomicsThe kinase NEK6 positively regulates LSD1 activity and accumulation in local chromatin sub-compartments (CSCs)
LSD1 is involved in multiple essential roles in mammalian biology and various modes of LSD1 regulation are described ranging from interaction with specific coregulators to distinct post translational modifications. Here we show that NEK6 positively influences LSD1 activity and we observe a strong c...
ORGANISM(S): Escherichia Coli 
2024-10-27 | PXD049227 | JPOST Repository
ProteomicsAcetylome, carbamylome, and phosphoproteome of RAW 264.7 cells treated with bacterial lipopolysaccharide
Proteome, acetylome/carbamylome, and phosphoproteome of RAW 264.7 cells treated for 24 h with bacterial lipopolysaccharide. Samples were digested with trypsin in a buffer containing urea or sodium deoxycholate, labeled with tandem mass tags, and fractionated by high pH reverse phase chromatography. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-05-23 | MSV000092020 | MassIVE
ProteomicsSite-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation (part 2)
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that regulate nuclear cellular processes. Here we used an augmented K0â??SUMO proteomics strategy to identify 40,765 SUMO acceptor sites and quantify their fractional contribution for 6,747 human proteins. Structuralâ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080869 | MassIVE
ProteomicsSite-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation (part 1)
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that regulate nuclear cellular processes. Here we used an augmented K0â??SUMO proteomics strategy to identify 40,765 SUMO acceptor sites and quantify their fractional contribution for 6,747 human proteins. Structuralâ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080812 | MassIVE
ProteomicsNmyc co-IP and post-translational modification identification
Endogenous and exogenous N-Myc co-IP were performed in neuroblastoma cell lines and 293T cells. The co-IP products were pretreated and subjected to LC-MS/MS analysis.
ORGANISM(S): Homo Sapiens 
2022-10-09 | PXD033457 |
ProteomicsSystems level analysis of histone H3 post-translational modifications reveals features of PTM crosstalk in chromatin regulation
Chromatin structure and function is maintained by dynamic protein-protein and protein-nucleic acid interactions. Histones are a family of proteins that are abundant chromatin constituents and that carry numerous post-translational modifications (PTMs). Histone PTMs mediate a variety of biological ac...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-16 | PXD002560 | Pride
Post-translational modification  crosstalk  histone  mass spectrometry  proteomics 
ProteomicsSpatial and temporal effects in protein post-translational modification distributions in the developing mouse brain
Protein post-translational modification (PTM) is a powerful way to modify the behavior of cellular proteins and thereby cellular behavior. Multiple recent studies of evolutionary trends have shown that certain pairs of protein post-translational modifications tend to occur closer to each other than ...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-11 | PXD003932 | Pride
Development Post-translational modifications Mouse brain 
ProteomicsTCellXTalk enables the detection of co-modified peptides for the study of protein post-translational modification cross-talk in T cells
Protein function is regulated by post-translational modifications (PTMs) that may act individually or interact with others in a phenomenon termed PTM cross-talk. Multiple databases have been dedicated to PTMs, including recent initiatives oriented to the in silico prediction of PTM interactions. The...
ORGANISM(S): Homo sapiens (Human) 
2018-09-19 | PXD010176 | Pride
Ptms Cross-talk Tcr activation T cells 
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