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ProteomicsEvidence for an RNAi-independent role of DICER-LIKE2 in conferring growth inhibition and basal antiviral resistance
Higher plants encode four or five DICER-LIKE (DCL) enzymes responsible for the production of small non-coding RNAs which function in RNA interference (RNAi). Different RNAi pathways in plants effect transposon silencing, antiviral defense and endogenous gene regulation. DCL2 acts genetically redunda...
ORGANISM(S): Arabidopsis Thaliana 
PXD046163 | panorama
ProteomicsThe dimeric SFiNX complex enables piRNA-guided co-transcriptional silencing through molecular condensate formation
Nuclear Argonaute proteins, guided by their bound small RNAs, orchestrate heterochromatin formation at transposon insertions and repetitive genomic loci. The molecular mechanisms that, besides recruiting heterochromatin effector proteins, are required for this silencing process are poorly understood...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2021-02-12 | PXD022010 | Pride
Cut up/dlc8 Co-transcriptional gene silencing Dimerization Condensate formation Pirna pathway Sfinx 
TranscriptomicsRNAi knock down of the DNA-repair enzyme and transcriptional co-activator APE1 in human HeLa cells
Transcriptional profiling was done following APE1/Ref1 silencing using conditional gene expression knockdown by RNA interference (RNAi) technology in HeLa cell lines. APE1 is a DNA-repair enzyme and transcriptional co-activator. Knockdown leads to cell-growth arrest, apoptosis and impairment in the ...
ORGANISM(S): Homo sapiens 
2009-02-02 | E-MEXP-1315 | biostudies-arrayexpress
ProteomicsDimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila
In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions. In Drosophila ovaries, piRNA-loaded Piwi detects nascent transposon transcripts and instructs heterochromatin formation through the Panor...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-01-26 | PXD022105 | Pride
Drosophila Pirna 
ProteomicsDimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila
In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions. In Drosophila ovaries, piRNA-loaded Piwi detects nascent transposon transcripts and instructs heterochromatin formation through the Panor...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-01-26 | PXD022103 | Pride
Drosophila Pirna 
TranscriptomicsGenomewide view of gene silencing by small interfering RNAs
RNA interference (RNAi) is an evolutionarily conserved mechanism in plant and animal cells that directs the degradation of messenger RNAs homologous to short double-stranded RNAs termed small interfering RNA (siRNA). The ability of siRNA to direct gene silencing in mammalian cells has raised the pos...
ORGANISM(S): Homo sapiens 
2005-12-14 | E-GEOD-3825 | biostudies-arrayexpress
GenomicspiRNA-guided co-transcriptional silencing coopts nuclear export factors
piRNA-guided co-transcriptional silencing coopts nuclear export factors
PRJNA498057 | ENA
TranscriptomicsRNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe [Illumina Genome Analyzer]
RNA interference (RNAi) is a gene silencing mechanism conserved from fungi to mammals. Small interfering RNAs are products and mediators of the RNAi pathway and act as specificity factors in recruiting effector complexes. The Schizosaccharomyces pombe genome encodes one of each of the core RNAi prot...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2014-01-23 | E-GEOD-54194 | biostudies-arrayexpress
ProteomicsVAL1 acts as an assembly platform co-ordinating co-transcriptional repression and chromatin 2 regulation at Arabidopsis FLC
• Polycomb (PcG) regulation is crucial for development across eukaryotes, but how PcG targets are specified is still incompletely understood. The slow timescale of cold-induced Polycomb Repressive Complex 2 silencing during vernalization at Arabidopsis thaliana FLOWERING LOCUS C (FLC) provides an ex...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-10-13 | PXD036548 | Pride
Asap Arabidopsis Vernalisation Polycomb Transcription factor Chromatin regulation Prc1 Epigenetics Gene silencing Orbitrap fusion 
GenomicsThe nuclear exosome is required for Piwi-piRNA mediated co-transcriptional gene silencing [RNA-seq]
The nuclear exosome is required for Piwi-piRNA mediated co-transcriptional gene silencing [RNA-seq]
PRJNA1146404 | ENA
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