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ProteomicsComplement Reporter Ion Quantification with a Quadrupole-Ion Trap Instrument
Proteomics workflows have traditionally been divided into discovery-based and targeted approaches, with instrumentation optimized for each. Discovery experiments typically utilize high-resolution analyzers such as the Orbitrap™, while targeted workflows rely on the sensitivity and specificity of tri...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Xenopus laevis (African clawed frog) 
2025-09-08 | PXD062540 | Pride
Stellar Complement reporter ion Quadrupole-ion trap Multiplexed shotgun proteomics 
ProteomicsAccurate, Sensitive, and Precise Multiplexed Proteomics using the Complement Reporter Ion Cluster
Quantitative analysis of proteomes across multiple time points, organelles, and perturbations is essential for understanding both fundamental biology and disease states. The development of isobaric tags (e.g. TMT) have enabled the simultaneous measurement of peptide abundances across several differe...
ORGANISM(S): Homo sapiens (Human) 
2018-04-23 | PXD009342 | Pride
Ms3 Tmtc Ms2 Tmt Quantitative multiplexed proteomics Label free 
UnknownAccurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster.
Not available
S-EPMC3771681 | biostudies-literature
UnknownExpanding Targeted Instrumentation for Discovery Applications: Complement Reporter Ion Quantification with a Quadrupole-Ion Trap Instrument.
Not available
S-EPMC12392913 | biostudies-literature
UnknownAccurate, Sensitive, and Precise Multiplexed Proteomics Using the Complement Reporter Ion Cluster.
Not available
S-EPMC6220677 | biostudies-literature
ProteomicsChronic sleep curtailment expediates brain aging by activating the complement and coagulation cascades in mice
Chronic sleep insufficiency is prevalent in modern society and has been associated with age-related neurodegenerative diseases. Loss of sleep accelerates the progression of neurodegeneration in animal models of neurological diseases. Here, we study whether chronic sleep curtailment leads to brain ag...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-10 | PXD060735 | Pride
Chronic sleep deprivation Complement system Brain aging Aging Sleep Proteomics 
ProteomicsCharacterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling
In the human body, proteins secreted into peripheral blood vessels are known as the secretome, and they represent the physiological or pathological status of cells. The unique response of cells to toxin exposure can be confirmed via secretome analysis, which can be used to discover toxic mechanisms ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD038016 | Pride
Alpha-amanitin  toxic mushroom  secretomes  exposure marker  complement component 3 
TranscriptomicsRNA-sequencing analysis of NGN3-GFP positive and negative cells purified from differentiating human embryonic stem cells
NGN3-eGFP could be used to mark endocrine progenitor cells and their progeny in differentiating hESCs, suggesting that profiling analysis of NGN3-eGFP+ cells could lead to the discovery of novel gene participation. Six batches of NGN3-eGFP+ and NGN3-eGFP -cells purified by FACS from a reporter hES c...
ORGANISM(S): Homo sapiens 
2014-09-12 | E-GEOD-54879 | biostudies-arrayexpress
ProteomicsGlobal Protein-Turnover Quantification in Escherichia Coli Reveals Cytoplasmic Recycling under Nitrogen Limitation
We quantify the degradation rates of 3.2k E. coli proteins under 12 conditions by combining heavy isotope labeling with complement reporter ion quantification and find that cytoplasmic proteins are recycled when nitrogen is limited.
ORGANISM(S): Escherichia coli 
2024-04-01 | PXD042444 | Pride
Isotope labeling Protein degradation Tmtpro 
ProteomicsN-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation and complement cascade
The cardiopulmonary nematode Angiostrongylus vasorum can cause severe disease in dogs, including coagulopathies manifesting with bleeding. We analysed A. vasorum excretory/secretory protein (ESP)-treated dog plasma and serum by N-terminome analysis using Terminal Amine Isotopic Labelling of Substrat...
ORGANISM(S): Angiostrongylus vasorum Canis familiaris (Dog) (Canis lupus familiaris) 
2025-05-07 | PXD056659 | Pride
Dog Serum French heartworm Plasma Tails 
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