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ProteomicsPhosphoproteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Targetable Kinases and Combination Treatments
Protein kinase inhibitors are amongst the most successful cancer treatments, but targetable kinases activated by gene fusions are rare in T-ALL (e.g., NUP214-ABL1). Nevertheless, leukemic blasts rely on enhanced kinase signaling to sustain dysregulated proliferation. Protein kinases can be hyper-act...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD024807 | Pride
Human Single-shot T-all Ptyr Label-free Phosphoproteomics T-cell acute lymphoblastic leukemia 
GenomicsDynamics of genomic clones in breast cancer patient xenografts at single cell resolution
Human cancers, including breast cancers, are comprised of clones differing in mutation content that evolve dynamically in space and time following principles of Darwinian evolution, underpinning important emergent features such as drug resistance and metastasis. Human breast cancer xenoengraftment i...
EGAS00001000952 | EGA
UnknownPioglitazone Enhances the Beneficial Effects of Glucocorticoids in Experimental Nephrotic Syndrome.
Not available
S-EPMC4855145 | biostudies-literature
UnknownIdentification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire.
Not available
S-EPMC10264507 | biostudies-literature
TranscriptomicsStudy of Foxp3 expression in tumor-associated macrophages
Using 5 differents approaches, including RNA sequencing, we demonstrated that macrophages that specifically infiltrate renal tumors, express the immunosuppressive transcription factor Foxp3. Examination of the Foxp3 mRNA expression in 3 different cell subsets (including CD4 T cells (CD4), type-1 mac...
ORGANISM(S): Mus musculus 
2014-05-31 | E-GEOD-56904 | biostudies-arrayexpress
TranscriptomicsGene profiling of the early healing rat medial collateral ligament
The objective of the study was to better understand the mechanism behind scar formation by identifying ECM factors and other unique genes differentially expressed during rat ligament healing via microarray. Rat medial collateral ligaments (MCL) were surgically transected or left intact. MCLs were co...
ORGANISM(S): Rattus norvegicus 
2013-06-06 | E-GEOD-47676 | biostudies-arrayexpress
ProteomicsFeasibility of phosphoproteomics to uncover oncogenic signalling in secreted extracellular vesicles using glioblastoma-EGFRVIII cells as a model
Cancer cells secrete extracellular vesicles (EVs) that contain molecular information, including proteins and RNA. Oncogenic signalling can be transferred via the cargo of EVs to recipient cells and may influence the behaviour of neighbouring cells or cells at a distance. This cargo may contain cance...
ORGANISM(S): Homo sapiens (Human) 
2023-10-17 | PXD046189 | Pride
Exosome Phospho-proteomics Glioblastoma multiforme Egfr Inka Lc-ms/ms Extracellular vesicles 
ProteomicsProteomic profiling of a large cohort of HCM patients: genotype-specific protein changes
Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular (LV) hypertrophy and diastolic dysfunction, which leads to LV outflow tract obstruction (LVOTO) in the majority of cases. Mutations in genes encoding sarcomeric proteins cause HCM and are identified in more than half o...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD012467 | Pride
Myectomy Hypertrophic cardiomyopathy Label-free Hcm Spectral counting 
Genomicsena-DATASET-BCCA-13-11-2014-22:09:20:907-954 - samples
Dynamics of genomic clones in breast cancer patient xenografts at single cell resolution
EGAD00001001066 | EGA
TranscriptomicsReciprocal communication between endometrial stromal cells and macrophages
Endometriosis is an inflammatory disease and bone marrow-derived cells are abundant in endometriotic lesions and in the peritoneal fluid of women with the disease. This study tested the hypothesis that reciprocal communication occurs between macrophages and cultured human endometrial stromal cells ...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-19834 | biostudies-arrayexpress
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