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ProteomicsToxoplasma conoid proteome by BioID
Toxoplasma gondii, a widely prevalent human and animal pathogen and a relative of the malaria-causing Plasmodium spp., is a member of the phylum Apicomplexa encompassing a large number of single-celled eukaryotic organisms that are obligate endoparasites of animals. Apicomplexans evolved multiple ad...
ORGANISM(S): Toxoplasma gondii RH 
2021-09-09 | PXD022785 | Pride
Imc Apicomplexa Apical complex Bioid Pellicle Toxoplasma Plasmodium Conoid 
ProteomicsAtomic models of the conoid from the human parasite Toxoplasma gondii
Apicomplexan parasites, responsible for toxoplasmosis, cryptosporidiosis, and malaria, invade host cells through a unique gliding motility mechanism powered by actomyosin motors and a dynamic organelle called the conoid. Using cryo-electron microscopy (cryo-EM) we determined structures of four essen...
ORGANISM(S): Toxoplasma gondii 
2025-11-14 | PXD068413 | Pride
Toxoplasma Parasite Human Conoid protein 
ProteomicsConoid extrusion serves as gatekeeper for entry of glideosome components into the pellicular space to control motility and invasion in Apicomplexa
Members of the apicomplexans are defined by apical cytoskeletal structures and secretory or-ganelles, tailored for motility and invasion. Gliding is powered by the actomyosin-dependent rearward translocation of apically secreted transmembrane adhesins. In Toxoplasma gondii, the conoid, composed of a...
ORGANISM(S): Toxoplasma gondii GT1 
2023-08-31 | PXD031816 | Pride
Apicomplexa Conoid extrusion Egress Motility Alphafold F-actin Invasion Toxoplasma gondii Hdx-ms Plasmodium berghei Preconoidal rings Micronemes 
UnknownAn apical ring protein essential for conoid complex assembly and daughter cell formation in Toxoplasma gondii.
Not available
S-EPMC12663574 | biostudies-literature
UnknownMolecular characterization of the conoid complex in Toxoplasma reveals its conservation in all apicomplexans, including Plasmodium species.
Not available
S-EPMC7951837 | biostudies-literature
UnknownRNG2 tethers the conoid to the apical polar ring in Toxoplasma gondii to enable parasite motility and invasion.
Not available
S-EPMC12671742 | biostudies-literature
UnknownExpansion microscopy provides new insights into the cytoskeleton of malaria parasites including the conservation of a conoid.
Not available
S-EPMC7951857 | biostudies-literature
UnknownSAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector.
Not available
S-EPMC4919640 | biostudies-literature
UnknownEssential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii.
Not available
S-EPMC7228768 | biostudies-literature
UnknownApicortin, a Constituent of Apicomplexan Conoid/Apical Complex and Its Tentative Role in Pathogen-Host Interaction.
Not available
S-EPMC8293464 | biostudies-literature
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