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ProteomicsA conserved cysteine acts as an endogenous antioxidant in the P-type plasma membrane H+-ATPase
Sulfur-containing amino acid residues function in antioxidative responses, which can be induced by the reactive oxygen species generated by excessive copper and hydrogen peroxide. In all Na+/K+, Ca2+, and H+ pumping P-type ATPases, a cysteine residue is present two residues upstream of the essential...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-10 | PXD022964 | Pride
Conserved cysteine Endogenous antioxidant Proton pump 
GenomicsConserved Spermatogonial Gene Networks Couple to Glutathione and Pentose Phosphate Metabolism but not Cysteine Biosynthesis
Conserved Spermatogonial Gene Networks Couple to Glutathione and Pentose Phosphate Metabolism but not Cysteine Biosynthesis
PRJNA685730 | ENA
ProteomicsThe role of RodAp-conserved cysteine residues in the Aspergillus fumigatus conidial surface organization
Immune inertness of Aspergillus fumigatus conidia, an airborne fungal pathogen, is attributed to its surface rodlet-layer made up of RodAp, a protein belonging to the hydrophobin family, characterized by eight conserved cysteine residues forming four disulfide bonding. Earlier, we showed that the co...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2021-02-18 | PXD020136 | Pride
Conidia Surface proteomics Roda Aspergillus fumigatus Lc-ms/ms 
TranscriptomicsThe global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA)
Abstract of associated menuscript; Quinones and alpha,beta-unsaturated carbonyls are naturally occurring electrophiles that target cysteine residues via thiol-(S)-alkylation. We analyzed the global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA...
ORGANISM(S): Bacillus subtilis 
2010-05-15 | E-GEOD-13925 | biostudies-arrayexpress
TranscriptomicsConserved Spermatogonial Gene Networks Couple to Glutathione and Pentose Phosphate Metabolism but not Cysteine Biosynthesis
Here, gene profiles in rat spermatogonial stem cell lines are compared to publicly available mouse, monkey and human spermatogonial gene profiles. Interestingly, rat spermatogonia expressed metabolic control factors Foxa1, Foxa2 and Foxa3. Germline Foxa2 was enriched in Gfra1Hi and Gfra1Low undiffer...
ORGANISM(S): Rattus norvegicus 
2020-12-17 | GSE163302 | GEO
ProteomicsFunctionality of plant mechanoproteins is based on dual role of cysteines
Forisomes are giant polyprotein complexes that undergo an immense and fully reversible conformational change from a spindle into a plug-like state triggered by Ca2+ and pH changes. Resembling their native function in plant vasculature, forisomes can act as valves to efficiently regulate flow in micr...
ORGANISM(S): Medicago Truncatula 
2021-11-08 | PXD027153 | JPOST Repository
ProteomicsA conserved cysteine-based redox mechanism sustains TFEB/HLH-30 activity under persistent stress
Mammalian TFEB and TFE3, as well as their ortholog in C. elegans HLH-30, play an important role in mediating cellular response to a variety of stress conditions, including nutrient deprivation, oxidative stress and pathogen infection. In this study we identify a novel mechanism of TFEB/HLH-30 regula...
ORGANISM(S): Homo sapiens (Human) 
2021-01-22 | PXD022258 | Pride
Hlh-30 Tfeb Glutathionylation Tfe3 Lysosomes 
ProteomicsSsimultaneous enrichment of cysteine-containing peptides and phosphopeptides using a novel Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in combination with TiO2 chromatography
Cysteine is a rare and conserved amino acid involved in most cellular functions. The thiol group of cysteine can be subjected to diverse oxidative modifications that regulate most physio-pathological states. Here, a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) was synthesized to selectively ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-13 | PXD002704 | Pride
Cyspat  reversible cys modifications  redox chemistry  protein phosphorylation  tio2 enrichment  cross-talk  proteomics 
UnknownConserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.
Not available
S-EPMC6715447 | biostudies-literature
UnknownThe Role of RodA-Conserved Cysteine Residues in the Aspergillus fumigatus Conidial Surface Organization.
Not available
S-EPMC7558875 | biostudies-literature
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