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MetabolomicsMicrobiomics combined metabolomics reveals Akkermansia modulating chicken gut microenvironment to protect from gamma coronavirus infection

In this study, we comprehensively investigated the influence of gut microbiota on gamma coronavirus replication in chickens. Using multi-omics approaches, we systematically examined microbial, viral and metabolic differences among adult chickens, young chickens and young chickens subjected to fec...

2025-08-17 | MTBLS12310 | MetaboLights
MetabolomicsBrain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication
While extensive research has examined the neuroinvasiveness of SARS-CoV-2, its relationship with brain maturation remains unclear. Using a multi-omics approach, we established cerebral organoids (CBOs) at day 60 (EB60) and day 120 (EB120) to model immature and mature developmental stages. We found t...
2026-06-18 | MTBLS14790 | MetaboLights
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
ProteomicsInhibiting coronavirus replication by chemical ER stress, including SARS-CoV-2 and MERS-CoV
Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV replication. We found that the ER stress inducer thapsigargin efficiently inhibits coro...
ORGANISM(S): Homo sapiens (Human) Middle East respiratory syndrome-related coronavirus Middle East respiratory syndrome-related coronavirus Severe acute respiratory syndrome coronavirus 2 Chlorocebus sabaeus 
2021-06-24 | PXD021222 | Pride
Thapsigargin Coronavirus Hcov-229e Sars-cov-2 Mers-cov 
TranscriptomicsFunctional genomic screens in human cells to identify host factors for SARS-CoV-2 and common cold coronaviruses
We performed genome-wide CRISPR KO screens in human Huh7.5.1 cells to select for mutations that render host cells resistant to viral infection by SARS-CoV-2, human coronavirus 229E and OC43.
ORGANISM(S): Homo sapiens 
2020-10-16 | E-MTAB-9638 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of the dynamic Innate Immune Responses in Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection causes an immune-mediated disease. We have recently shown that SARS-CoV-induced epithelial Calu-3 cytokines could exacerbate and dampen host inflammatory and T cell responses, respectively, through modulating the functions...
ORGANISM(S): Homo sapiens 
2010-02-24 | E-GEOD-17400 | biostudies-arrayexpress
ProteomicsProximity biotinylation and LC-MSMS identification of the molecular microenvironment of coronavirus replication complexes
To investigate virus-host interactions at the site of coronavirus replication, we developed a biotin-based proximity labelling approach by engineering a promiscuous biotin ligase, BirA-R118G, within the coronavirus replication and transcription complex (RTC). BirA-R118G was fused to non-structural p...
ORGANISM(S): Murine hepatitis virus strain A59 Mus musculus (Mouse) 
2019-01-16 | PXD009975 | Pride
L929 mouse fibroblast Lc-msms Viral replication complex Bira-r118g Mouse hepatitis virus Bioid 
ProteomicsThe Global Phosphorylation Landscape of SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, has infected over 3 million people worldwide and caused over 200,000 deaths since it emerged in late 2019. There is an urgent need to develop therapies that can limi...
ORGANISM(S): Chlorocebus Aethiops (ncbitaxon:9534) 
2020-07-15 | MSV000085759 | MassIVE
TranscriptomicsTranscriptomic landscape of murine coronavirus infection in the lung
Impaired type I interferon (IFN) responses are predictive of severe disease during pulmonary coronavirus infection. Insufficient IFN-responsiveness is associated with viremia and hypercytokinemia, however the resolution of IFN-dependent innate immune responses in the lungs remains limited. Here, we ...
ORGANISM(S): Mus musculus 
2023-01-02 | E-MTAB-11781 | biostudies-arrayexpress
TranscriptomicsAbsence of host innate immune responses in SARS-CoV-infected ferrets upon subsequent challenge
To further investigate the underlying mechanisms of severe acute respiratory syndrome (SARS) pathogenesis and evaluate the therapeutic efficacy of potential drugs and vaccines it is necessary to use an animal model that is highly representative of the human condition in terms of respiratory anatomy,...
ORGANISM(S): Mustela putorius furo 
2013-05-28 | E-GEOD-11704 | biostudies-arrayexpress
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