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Proteomics14-3-3 protects AMPK phosphorylated TET2 from dephosphorylation by PP2A
Ten-eleven translocation-2 (TET2) is a member of the methylcytosine dioxygenase family of enzymes implicated in cancer and in aging due to its role as a global epigenetic modifier. TET2 has a large N-terminal domain followed by a catalytic C-terminal. Previous reports have demonstrated that the cata...
ORGANISM(S): Homo sapiens (Human) 
2020-01-13 | PXD016160 | Pride
5hmc Ampk Pp2a Tet2 Post-translational modification 14-3-3 
ProteomicsProteomic Analysis of Diabetic Retinas
As a metabolic disease, diabetes often leads to health complications such as heart failure, nephropathy, neurological disorders, and vision loss. Diabetic retinopathy (DR) affects as many as 100 million people worldwide. The mechanism of DR is complex and known to impact both neural and vascular com...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-16 | PXD044269 | Pride
Retina Proteomics diabetes mellitus Mouse 
TranscriptomicsProcessing of Drosophila endo-siRNAs depends on a specific Loquacious isoform
Drosophila melanogaster expresses three classes of small RNAs, which are classified according to their mechanisms of biogenesis. MicroRNAs are ~22-23-nt, ubiquitously expressed small RNAs that are sequentially processed from hairpin-like precursors by Drosha/Pasha and Dcr-1/Loquacious complexes. Mic...
ORGANISM(S): Drosophila melanogaster 
2009-07-30 | E-GEOD-17171 | biostudies-arrayexpress
UnknownSerious Falls in Middle-Aged Veterans: Development and Validation of a Predictive Risk Model.
Not available
S-EPMC7744431 | biostudies-literature
ProteomicsEarly-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling
Protein translation (PT) declines with age in invertebrates, rodents, and humans. It has been assumed that elevated PT at young ages is beneficial to health and PT ends up dropping as a passive byproduct of aging. In Drosophila, we show that a transient elevation in PT during early-adulthood exerts ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-10-24 | PXD044118 | Pride
Proteostasis Aging Proteomics Lcms2 Drosophila 
ProteomicsProteomic Analysis of Diabetic Retinas (proteoglycomics data only)
As a metabolic disease, diabetes often leads to health complications such as heart failure, nephropathy, neurological disorders, and vision loss. Diabetic retinopathy (DR) affects as many as 100 million people worldwide. The mechanism of DR is complex and known to impact both neural and vascular com...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-16 | PXD044270 | Pride
Mouse Proteomics Retina Diabetes mellitus 
ProteomicsLipid droplet-targeted APEX proteome
Lipid droplet (LD) function is regulated by a complement of integral and peripheral proteins that associate with the LD phospholipid monolayer. Defining the composition of the LD proteome has remained a challenge due to the presence of contaminating proteins in LD-enriched buoyant fractions. To over...
ORGANISM(S): Homo sapiens (Human) 
2017-12-22 | PXD007695 | Pride
Lipid droplet Apex Erad 
ProteomicsEndoplasmic reticulum di-glycine modified proteome under p97/VCP inhibition
Endoplasmic reticulum (ER)-associated degradation (ERAD) mediates the proteasomal clearance of proteins from the early secretory pathway. In this process, ubiquitinated substrates are extracted from membrane-embedded dislocation complexes by the AAA ATPase VCP and targeted to the cytosolic 26S prote...
ORGANISM(S): Homo sapiens (Human) 
2018-03-12 | PXD008842 | Pride
Erad Digly Ubiquitin 
TranscriptomicsPolycomb Repressor Complex2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype
These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results show that H3K27me3-enriched genes show no de-repression in REST-/- ESCs, while REST target genes show significant de-repression. RNA-seq was ...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-59442 | biostudies-arrayexpress
UnknownType 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated.
Not available
S-EPMC8282661 | biostudies-literature
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