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MetabolomicsInfection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication
Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread...
2018-10-22 | MTBLS652 | MetaboLights
ProteomicsMulti-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures in Huntington's disease mouse models
Huntington's disease (HD) is a debilitating progressive neurodegenerative disorder that has profound effects on an individual's cognitive, motor, and behavioral functions. HD is caused by mutation in the huntingtin (HTT) gene that results in CAG repeat expansion and production of an aggregation-pron...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2024-04-10 | MSV000094509 | MassIVE
Proteomics,MultiomicsInteractome analysis of PYHIN immune regulators
The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins. By design...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079955 | MassIVE
ProteomicsSystematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity
Rapid and dynamically shifting protein-protein interactions (PPIs) underlie the capacity of cells to recognize viral infections and ignite the downstream cascades that constitute the innate-immune response. Herpesviruses share an ancient history of coevolution with their hosts and have developed rec...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2021-05-11 | PXD023167 | Pride
Thermal proteome profiling  herpes simplex virus 1  protein complexes  protein interactions  ifi16  dna sensing  dna-pk  dna damage response  innate immunity 
ProteomicsKSHV ORF18 TurboID in human iSLK cell lines
Beta- and gamma-herpesviruses transcribe their late genes in a manner distinct from host transcription. This process is directed by a complex of viral transcriptional activator proteins that hijack cellular RNA polymerase II, and an unknown set of additional factors. We employed proximity labeling t...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD039694 | Pride
Human Kshv Lc-msms Orf18 Turboid 
ProteomicsMouse T-cell LC-MSMS from WT and MTDH KO
This study uncovers host Metadherin (MTDH) as a pivotal regulator of systemic tumor progression, orchestrating liver metabolism and CD8⁺ T cell immunity. Tumor-derived extracellular vesicles prompt Kupffer cells to release TNFα and TGF-β, which, through MTDH-driven NF-κB signaling, suppress hepatic ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-29 | PXD064796 | Pride
Mouse Timstof ultra Tumor T-cell 
ProteomicsRegulation of Global Lysine Lactylation during HCMV Infection
Aerobic glycolysis is a hallmark of virus-infected cells, leading to substantial accumulation and secretion of lactate. However, the regulatory roles of lactate during viral infections are still poorly understood. Here, we report that human cytomegalovirus (HCMV) infection leverages lactate to induc...
ORGANISM(S): Cytomegalovirus Homo sapiens (Human) 
2024-11-23 | PXD057709 | Pride
Human cytomegalovirus Lysine lactylation Alanine Lactyllysine Aars1 
ProteomicsGlobal Lysine Lactylation Dynamics during HCMV and HSV-1 Infections
Aerobic glycolysis is a hallmark of virus-infected cells, leading to substantial accumulation and secretion of lactate. However, the regulatory roles of lactate during viral infections are still poorly understood. Here, we report that human cytomegalovirus (HCMV) infection leverages lactate to induc...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 Human cytomegalovirus (HHV-5) (Human herpesvirus 5) 
2024-11-23 | PXD055230 | Pride
Hcmv Hsv-1 Lactyllysine Fibroblast Lactylation 
ProteomicsAP-MS analysis of sirtuin-2 interactions and whole-cell proteome analysis in human fibroblasts
Sirtuins are NAD+-dependent deacylases with diverse enzymatic activities and substrates. They were implicated in regulation of cancer progression, neurodegeneration, aging, and viral infection. Sirtuin-2 localizes to the cytoplasm and is known to deacetylate alpha-tubulin. Current knowledge on sirtu...
ORGANISM(S): Homo sapiens (Human) 
2016-08-12 | PXD004212 | Pride
Human fibroblasts Lc-ms/ms 
ProteomicsAP-MS analysis of sirtuin-4 interactions in human fibroblasts
Sirtuins (SIRTs) form a critical family of nicotinamide adenine dinucleotide (NAD)-dependent enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, SIRTs4-7 have little to no deacetylase activity, and a robust catalytic activity for mitochondrial SIRT4 h...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-04 | MSV000079557 | MassIVE
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