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Proteomicsdynamic proteomics of mesenchymal stem cells in critical limb ischemia
Mutant MetRS in MSCs allows efficient and specific identification of dynamic cell proteomics in situ, which reflect the functions and adaptive changes of MSCs that may be leveraged to understand and improve stem cell therapy in critical limb ischemia
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD026954 | Pride
Mouse muscle ms 
ProteomicsMuscle Proteome of Critical Limb Ischemia Patients
This is a TMT-labeled proteomics analysis of human skeletal muscle specimens obtained from the following groups: older adult controls, critical limb ischemia patients undergoing surgical intervention, and critical limb ischemia patients undergoing limb amputation.
ORGANISM(S): Homo Sapiens (human) 
2021-10-06 | PXD021849 | JPOST Repository
ProteomicsIdentification of the initial molecular changes in response to Circulating Angiogenic Cells-mediated therapy in Critical Limb Ischemia
Circulating angiogenic cells (CACs) constitute promising candidates for cell therapy in critical limb ischemia (CLI) due to their assigned vascular regenerative properties. A label free MS-based quantitative approach was performed to identify protein changes related. We analyzed the initial molecula...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD017661 | Pride
Critical limb ischemia Angiogenesis Circulating endothelial cells Mouse Cell movement 
ProteomicsInterventional- and amputation-stage muscle proteomes in the chronically threatened ischemic limb
Background: Despite improved surgical approaches for chronic limb threatening ischemia (CLTI), amputation rates remain high and contributing tissue-level factors remain unknown. Objective: The purpose of this study was twofold: 1) to identify differences between the healthy adult and CLTI limb mu...
ORGANISM(S): Homo Sapiens (human) 
2022-04-21 | PXD025810 | JPOST Repository
ProteomicsLong-term changes following pre-conditioned circulating angiogenic cells therapy in critical limb ischemia
Critical limb ischemia (CLI), results from a severe blockade of the arterial vessels, is usually correlated to atherosclerosis. Circulating angiogenic cells (CACs) constitute a good alternative as CLI cell therapy due to their vascular regenerative potential, although the mechanisms of action of the...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD024132 | Pride
Neovascularization Circulating angiogenic cells Immune cells Atherosclerotic secretome Critical limb ischemia 
ProteomicsUnraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia.
Critical limb threatening ischemia (CLTI), the most severe manifestation of peripheral artery disease, results from the chronic blockade of peripheral vessels, usually induced by atherosclerosis. CLTI patients suffer from high risk of amputation of the lower extremities and elevated mortality rates,...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-25 | PXD046843 | Pride
Mscs Critical limb-threatening ischemia Proteomics Cell therapy Adipose tissue Ecfcs 
ProteomicsProteomic analysis of vascular tissue from critical limb ischemia mouse models treated with Etrinabdione
Vasculogenic therapies have been investigated for the treatment of peripheral artery disease (PAD) with very limited success in clinical trials. The isoform PP2A (protein phosphatase 2)/B55alpha inhibits the activity of the prolyl hydroxylase 2 (PHD2) and activates the hypoxia inducing factor-1alpha...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-03 | PXD050360 | Pride
Vascular tissue Critical limb ischemia 
TranscriptomicstRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis
Ischemic injuries will lead to necrotic tissue damage, and post-ischemia angiogenesis plays critical roles in blood flow restoration and tissue recovery. Recently, several types of small RNAs have been reported to be involved in this process. In this study, we first generated a rat brain ischemic mo...
ORGANISM(S): Rattus norvegicus 
2016-03-16 | E-GEOD-70473 | biostudies-arrayexpress
UnknownOutcomes of Orbital Atherectomy in Patients with Critical Limb Threatening Ischemia and Diabetes.
Not available
S-EPMC10103796 | biostudies-literature
TranscriptomicsmRNA expression profile of Tie2 monocytes in limb ischemia patients and controls
Tie2-expressing monocytes do not appear to effect revascularisation in critical limb ischemia (CLI) patients, despite a large body of evidence demonstrating their pro-angiogenic potential when isolated from control patients. In order to understand what might cause this loss of angiogenic function, w...
ORGANISM(S): Homo sapiens 
2016-07-21 | E-GEOD-84626 | biostudies-arrayexpress
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