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Genomics
Extracellular filaments revealed by affinity capture cryo-electron tomography.
We have applied cryo-tomography and proteomics analyses to centrosomes isolated from young lamb thymus– a convenient source of quiescent and differentiated cells. Those analyses have allow us to better depict the protein organization joining the two centrioles in such a cellular system, in the form...
ORGANISM(S): Ovis aries 
2019-11-08 | PXD003928 | Pride
Dysfunction in lysosomal membrane proteins and their associated complexes impairs the lysosome's essential role as a key signaling hub within the cell. This disruption underlies severe neurological disorders, such as lysosomal storage diseases and cancer. While direct visualization of the proteomic ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD055923 | Pride
Viral infections invariably require the dismantling of capsids enclosing viral genomes. Yet, discrete intermediates and host factors supporting nucleic acid uncoating in susceptible cells are largely elusive. Using cryo-electron tomography (cryo-ET) and superresolution microscopy we show that human ...
ORGANISM(S): Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) Homo sapiens (Human) 
2026-04-14 | PXD076818 | Pride
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