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ProteomicsThe E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron
We identify cyclic imides, previously overlooked post-translation modifications, across different tissues (red blood cells and bovine lens) and human-derived cell lines and found that these modifications are globally regulated by cereblon.
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-07-28 | PXD030091 | Pride
Degron Lc-ms/ms Cyclic imide Cereblon Ptm 
ProteomicsThe E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron
Global quantitative proteomics of cells treated with the immunomodulatory drug pomalidomide or dipeptide degrons; global quantitative proteomics of cells treated with heterobifunctional degraders embedded with thalidomide or cyclic imide degrons; gloabl quantitative proteomics of red blood cells to ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-28 | PXD025413 | Pride
Degron Cereblon Cyclic imide Imid E3 
ProteomicsThe E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron
The E3 ligase factor cereblon (CRBN) is a target of thalidomide and lenalidomide, which are therapeutic agents used in the treatment of hematopoietic malignancies and as ligands for targeted protein degradation. These agents are proposed to mimic a naturally occurring degron; however, the structural...
ORGANISM(S): Homo sapiens (Human) 
2022-07-28 | PXD034248 | Pride
Degron Cyclic imide Cereblon Protac 
ProteomicsPCMT1 generates the C-terminal cyclic imide degron on CRBN substrates
The E3 ligase substrate adapter cereblon (CRBN), the primary target of clinical agents thalidomide and lenalidomide, recognizes endogenous substrates bearing the C-terminal cyclic imide modification. Although C-terminal cyclic imides can form spontaneously, an enzyme that regulates the formation of ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-05 | PXD061730 | Pride
Crbn Pcmt1 C-terminal cyclic imide Glul Ppa1 
ProteomicsGenesis and regulation of C-terminal cyclic imides from protein damage
C-Terminal cyclic imides are post-translational modifications (PTMs) that can arise from spontaneous intramolecular cleavage of asparagine or glutamine residues resulting in a form of irreversible protein damage. These protein damage events are recognized and removed by the E3 ligase substrate adapt...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD054016 | Pride
Protein cleavage Cyclic imide Cereblon Protein damage Post-translational modifications Deamidation 
UnknownThe contribution of cyclic imide stereoisomers on cereblon-dependent activity.
Not available
S-EPMC12117711 | biostudies-literature
UnknownThe E3 ligase adapter cereblon targets the C-terminal cyclic imide degron.
Not available
S-EPMC10316063 | biostudies-literature
ProteomicsA method for the detection and enrichment of endogenous cereblon substrates
C-Terminal cyclic imides are posttranslational modifications on proteins that are recognized and removed by the E3 ligase substrate adapter cereblon (CRBN). Despite the observation of these modifications across the proteome by mass spectrometry-based proteomics, an orthogonal and generalizable metho...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-08-11 | PXD061728 | Pride
C-terminal cyclic imide enrichment Crbn 
UnknownIron-Binding and Anti-Fenton Properties of Novel Amino Acid-Derived Cyclic Imide Dioximes.
Not available
S-EPMC6826749 | biostudies-literature
UnknownStructural Analysis of the Complexation of Uranyl, Neptunyl, Plutonyl, and Americyl with Cyclic Imide Dioximes.
Not available
S-EPMC6645112 | biostudies-literature
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