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Extracellular cysteine cathepsins are known to drive cancer progression, but besides degradation of extracellular matrix proteins little is known about their physiological substrates and thus the molecular mechanisms they deploy. One of the major mechanisms used by other extracellular proteases to f...
ORGANISM(S): Homo sapiens (Human) 
2015-06-23 | PXD002192 | Pride
Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and trypsin-like proteases lack strict specificity determining P1 pocket, was calling for innovative approaches. Proteomic analysis of cell lysates with human cathepsins K, V, B, L, S, and F identified 30,000 cl...
ORGANISM(S): Homo sapiens (Human) 
2023-03-29 | PXD041185 | Pride
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