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GenomicsChIP-Seq analysis of BATF, IRF4, the Jun proteins, and histone modifications in effector CD8+ T cells
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54191 | biostudies-arrayexpress
OtherCompartment resolved reference proteome map from highly purified na-ve, activated, effector, and memory CD8+ murine immune cells.
Data from ProteomeXchange, PXD ID: PXD001065. Experiment: Aus7, file: Aus7_35.mzml. Published as part of Proteomics. 2015 Jan 23 . From the Abstract: {{i}} In this study, we investigated the proteome of four cytotoxic T cell subtypes; na-ve, recently activated effector, effector and memory cells. C...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310006565 | GPMDB
Resource Reanalysis 
ProteomicsComparative analysis of intra- and extracellular vesicles from cytotoxic CD8+ αβ T cells and γδ T cells
Although belonging to different branches of the immune system, cytotoxic CD8+ αβ T cells and γδ T cells utilize common cytolytic effectors including FasL, granzymes, perforin and granulysin. The effector proteins are stored in different subsets of lysosome-related effector vesicles (LREVs) and relea...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055377 | Pride
Exosomes Lysosome-related effector vesicles (lrevs) Cd8+ t cells Αβ t cells Cytotoxic granules Cytotoxic effector proteins Γδ t cells Cytotoxic t cells Proteomic profiling Extracellular vesicles (evs) 
ProteomicsCompartment resolved reference map from highly purified naive, activated, effector and memory CD8+ cells
Differentiation of CD8+ T lymphocytes into effector and memory cells is key for an adequate immune response and relies on complex interplay of pathways that convey signals from cell surface to nucleus. In this study, we fractionated four CD8+ T cell subtypes; naïve, recently activated effector, eff...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-02-29 | MSV000079540 | MassIVE
TranscriptomicsComparison of gene expression profiles of naïve and in vitro effector CD8+ T cells from wild-type and BATF-/- mice
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54215 | biostudies-arrayexpress
ProteomicsThe impact of hypoxia on the cytotoxic T lymphocyte proteome
Metabolic and nutrient-sensing pathways play an important role in controlling the efficacy of effector T cells. Oxygen is a critical regulator of cellular metabolism. However, during immune responses T cells must function in oxygen-deficient, or hypoxic, environments. Here, we used high resolution m...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-20 | PXD026223 | Pride
Cd8 t cells Oxygen sensing Hypoxia Ctls Cytotoxic t lymphocytes 
ProteomicsInterleukin-2 shapes the cytotoxic T cell proteome and immune-environment sensing
Interleukin-2 (IL-2) and Janus kinases (JAKs) regulate transcriptional programs and protein synthesis to control the differentiation of effector CD8+ cytotoxic T cells (CTL). Using high-resolution mass spectrometry, we have generated an in-depth characterisation of how IL-2 and JAKs configure the CT...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-17 | PXD008112 | Pride
Proteomics Jak1 Il-2 Interleukin-2 Jak3 Lymphocytes 
OtherQuantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks.
Data from ProteomeXchange, PXD ID: PXD001076. Experiment: JG-N2, file: JG-N2-12.mzml. Published as part of Mol Cell Proteomics. 2014 Sep 29 . From the Abstract: {{i}} ... We used Stable Isotope of Amino acids in Culture (SILAC) combined with phosphopeptide enrichment and quantitative mass-spectrome...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320004050 | GPMDB
Resource Reanalysis 
ProteomicsQuantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks
The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population. We used Stable Isotope Labelling of Amino acids in Culture (S...
ORGANISM(S): Mus musculus (Mouse) 
2014-10-03 | PXD001076 | Pride
Silac Pkd2 Phosphoproteomics Lymphocytes 
ProteomicsActinomycin D treated cytotoxic T lymphocytes
Effector cytotoxic T lymphocytes (CTLs) are critical for ridding the body of infected or cancerous cells. Recognition of an antigenic ligand by the CTL’s T cell receptor (TCR) triggers a signalling cascade that ultimately results in the targeted release of cytolytic granules and/or secretion of cyto...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-16 | PXD034920 | Pride
T cell Transcription Dia Mouse Actinomycin d 
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