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MetabolomicsComparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells

Introduction

Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by proinflammatory immune cells, transitioning to the repair and healing phase is halted. T cells may exacerbate the proinflammatory mil...
2025-07-09 | MTBLS9800 | MetaboLights
ProteomicsComparative analysis of intra- and extracellular vesicles from cytotoxic CD8+ αβ T cells and γδ T cells
Although belonging to different branches of the immune system, cytotoxic CD8+ αβ T cells and γδ T cells utilize common cytolytic effectors including FasL, granzymes, perforin and granulysin. The effector proteins are stored in different subsets of lysosome-related effector vesicles (LREVs) and relea...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055377 | Pride
Exosomes Lysosome-related effector vesicles (lrevs) Cd8+ t cells Αβ t cells Cytotoxic granules Cytotoxic effector proteins Γδ t cells Cytotoxic t cells Proteomic profiling Extracellular vesicles (evs) 
OtherQuantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks.
Data from ProteomeXchange, PXD ID: PXD001076. Experiment: JG-N2, file: JG-N2-12.mzml. Published as part of Mol Cell Proteomics. 2014 Sep 29 . From the Abstract: {{i}} ... We used Stable Isotope of Amino acids in Culture (SILAC) combined with phosphopeptide enrichment and quantitative mass-spectrome...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320004050 | GPMDB
Resource Reanalysis 
TranscriptomicsIn vivo gene expression data from wild type and CTLA-4 KO 5C.C7 T cells
CTLA-4 is thought to inhibit effector T cells both intrinsically, by competing with CD28 for B7 ligands, and extrinsically, through the action of regulatory T cells. We studied in vivo responses of normal and CTLA-4-deficient antigen-specific murine effector CD4+ T cells. In order to do these studie...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-37563 | biostudies-arrayexpress
ProteomicsM.musculus - T cell, SC (Hukelmannetal,natimmunol2016)
abundance based on Spectral counting, Interaction consistency score: 16.2, Coverage: 30
ORGANISM(S): 10090 
2016-00-00 | 190918057 | PAXDB
ProteomicsQuantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks
The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population. We used Stable Isotope Labelling of Amino acids in Culture (S...
ORGANISM(S): Mus musculus (Mouse) 
2014-10-03 | PXD001076 | Pride
Silac Pkd2 Phosphoproteomics Lymphocytes 
GenomicsMurine cytotoxic CD4 T cells
Murine cytotoxic CD4 T cells
PRJNA743066 | ENA
TranscriptomicsA microRNA-directed program of cytotoxic CD8+ T cell differentiation
Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTL, and that deletion or depletion of Dicer in mouse or human activated CD8+ T cells causes upregulation of perforin, granzyme an...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-51393 | biostudies-arrayexpress
ProteomicsIdentification of different human CD8 T cell subsets by superior cytotoxicity in human T cells
Cytotoxic CD8+ T cells can effectively kill target cells by producing cytokines, chemokines and granzymes. Expression of these effector molecules is however highly divergent, and tools that identify and pre-select potent killer cells are lacking. Human CD8+ T cells can be divided into IFNGand IL-2 p...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012874 | Pride
Human Il2 Ifng Cd8 T cells 
ProteomicsTargeting the histone methyltransferase DOT1L rewires CD8 T cells and enhances their intrinsic cytotoxic activity towards tumor cells
Insights into the epigenetic mechanisms of CD8 T cell differentiation are delivering novel opportunities for modulating fate decisions and immune responses. The histone methyltransferase DOT1L is emerging as central epigenetic regulator in immune cells. However, its cell-intrinsic role in CD8 T cell...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD057606 | Pride
Lc-msms Epigenetics Cytotoxic cell Epigenetic targeting T cell differentiation Histone methylation Tumor immunology 
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