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ProteomicsThe effect of Venetin-1 against cyclophosphamide-induced lung toxicity in mice
Cyclophosphamide (CPAm) is a widely used chemotherapeutic agent that exhibits potent anti-cancer properties but is often associated with debilitating side effects. Despite its efficacy, the management of CPAm-induced toxicities remains a significant clinical challenge. There has been growing interes...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052794 | Pride
Cyclophosphamide Proteomics Lungs Earthworm Swath Mass spectrometry Immunosuppression 
ProteomicsMembrane vesicles of Pectobacterium as an underappreciated protein secretion system
Pectobacterium are Gram-negative rods of the family Pectobacteriaceae. They are the causative agent of soft rot diseases of crops and ornamental plants. However, their virulence mechanisms are not yet fully elucidated. Membrane vesicles (MVs) are universally released by bacteria and are be-lieved to...
ORGANISM(S): Pectobacterium zantedeschiae 
2022-02-15 | PXD029090 | Pride
Bacterial membrane vesicles  pectobacterium  proteomic analysis  plant pathogens  bacterial virulence 
ProteomicsLon protease is important for growth under stressful conditions and pathogenicity of the phytopathogen, bacterium Dickeya solani.
The Lon protein is a protease implicated in virulence of many pathogenic bacteria, including some plant pathogens. However, little is known about the role of Lon in bacteria from genus Dickeya. This group of bacteria include important potato pathogens, with the most aggressive species, D. solani. ...
ORGANISM(S): Dickeya solani 
2021-09-09 | PXD018297 | Pride
Dickeya solani Swath Lc-ms/ms 
ProteomicsIdentification oAnti-Candida albicans effect of the new antifungal compound Venetin-1 obtained from earthworms versus Amphotericin B
Candida albicans is a commensal organism that can cause disease in individuals with weakened and compromised immune systems. These fungi can cause superficial or invasive infections associated with high mortality. The aim of this study was to compare the activity of the new antifungal compound Venet...
ORGANISM(S): Candida albicans (Yeast) 
2026-09-09 | PXD074441 | Pride
Candida albicans Proteomic analysis Flow cytometry Venetin-1 Microscopic analysis Amphotericin b 
ProteomicsProteomic response of A549 lung cancer cell line to Venetin-1
Earthworm's celomic fluid has long attracted scientists' interest due to its toxic properties. It has been shown that subjecting it to a short heating at 70 ° C, which effectively reduces the toxicity to healthy cells, and demonstrates the selective action of the obtained Venetin-1 preparation again...
ORGANISM(S): Homo sapiens (Human) 
2023-06-02 | PXD034121 | Pride
Proteomics Swath Venetin-1 Earthworms Coelomic fluid 
ProteomicsFor origin melting Rep nucleoprotein complex accommodates both dsDNA and ssDNA of DUE
The replication initiation proteins interact dsDNA located at replication origin and ssDNA of DNA unwinding element (DUE), formed as a result of the destabilization of the double-stranded helix of AT-rich origin region. It is a critical step in the DNA replication initiation; however, the structure ...
ORGANISM(S): Escherichia coli 
2024-01-26 | PXD032398 | Pride
Dna replication Rep proteins Protein-dna interaction Replication initiators Origin opening 
ProteomicsNovel Venetin-1 nanoparticle from earthworm coelomic fluid as a promising agent for the treatment of non-small cell lung cancer
The present research shows the antitumor activity of a protein-polysaccharide complex Venetin-1 obtained from the fluid of Dendrobaena veneta earthworms against A549 cancer cells. The investigations are a continuation of experiments on the antitumor activity of the coelomic fluid from this species. ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-07 | PXD034132 | Pride
Dendrobaena veneta Cancer A549 Spr 
ProteomicsQuantitative analysis of rtPA-associated ICH protein serum and plasma biomarkers in acute ischemic stroke
Acute stroke, with ischemic stroke comprising 80% of all cerebrovascular incidents, has been recognized as one of the core problems in clinical medicine in need of prevention and treatment. Intravenous rtPA is the mainstay and the highest class evidence based method of acute ischemic stroke treatme...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD021713 | Pride
Plasma Serum Stroke Swath-ms 
ProteomicsThree Microbial Musketeers of the Seas: Shewanella baltica, Aliivibrio fischeri and Vibrio harveyi, and their adaptation to different salinity probed by a proteomic approach
Osmotic changes are common challenges for marine microorganisms. Bacteria developed numerous ways of dealing with this stress, including reprogramming of global cellular processes, however, many molecular details were obtained only for the model bacteria. In this work we asked what is the basis of t...
ORGANISM(S): Vibrio harveyi Aliivibrio fischeri Shewanella baltica 
2022-02-17 | PXD029628 | Pride
Shewanella baltica Aliivibrio fischeri Vibrio harveyi Osmotic stress Salinity challenge Lc-ms/ms 
ProteomicsGenome-wide identification of Dickeya solani genes regulated in response to potato (Solanum tuberosum L.) and bittersweet nightshade (Solanum dulcamara L.) tissues
The purpose of this study was to identify and characterize the D. solani genes that are differentially expressed in the early stages of infection of S. tuberosum (model for primary crop host) and S. dulcamara (model plant for alternative non-crop host) by a process of a random mutagenesis of D. sola...
ORGANISM(S): Solanum tuberosum (Potato) 
2021-09-09 | PXD017118 | Pride
Ms/ms Protein id Plant extract Fasp 
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