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UnknownPrognostic potential of CUL3 ligase with differential roles in luminal A and basal type breast cancer tumors.
Not available
S-EPMC11213933 | biostudies-literature
ProteomicsDisease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradationDisease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
E3 ubiquitin ligases of the Cullin RING Ligase (CRL) family assemble into multiprotein complexes to diversify substrate adaptors and ensure selectivity in substrate engagement for degradation. Here we show a novel mechanism whereby mutations in substrate adaptors can drive neo-substrate degradation ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031683 | Pride
Medulloblastoma Kbtbd4 Ubiquitin Corest Epigenetic remodelling 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
Abstract F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma ste...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069593 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma stem cell su...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069542 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma stem cell su...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069496 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsCyclin F - EXO1 axis controls cell cycle dependent execution of double strand break repair
Ubiquitination is a crucial post-translational modification required for the proper repair of DNA double-strand breaks (DSBs) induced by ionising radiation (IR). DSBs are mainly repaired through homologous recombination (HR) when template DNA is present and non-homologous end joining (NHEJ) in its a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051841 | Pride
Microhomology-mediated end joining And cancer Ionising radiation Dna damage repair Dna damage response Dna double strand breaks Exo1 Ubiquitination Single strand annealing Cell cycle Cyclin f 
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