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ProteomicsZAP-70 promotes microenvironment interactions and increases protein-translation in chronic lymphocytic leukemia
The expression of ZAP-70 in a subset of CLL patients strongly correlates with a more aggressive clinical course, though the exact underlying mechanisms remain elusive. The ability of ZAP-70 to enhance B cell receptor (BCR) signaling, independently of its kinase function, likely contributes. Here we ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-26 | PXD019465 | Pride
Zap70 Q-plex_rime Leukemia 
ProteomicsRetroviral transduction of NOTCH1 into primary human Chronic Lymphocytic Leukemia cells unravels immune escape-mechanisms
Functional studies to investigate gene mutations recurrent in B cell lymphoma have been hampered by the inability to genetically manipulate primary cells, attributed to low transduction efficacy and procedure-associated toxicity. Alternative approaches utilize cell lines and mouse models, which ofte...
ORGANISM(S): Homo sapiens (Human) 
2022-08-26 | PXD024112 | Pride
Notch1 Mutated gene Chronic lymphocytic leukemia (cll) Co-activator ciita Mantle cell lymphoma (mcl) Hla-class ii locus 
ProteomicsAZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells
Phosphorylation of RNA polymerase II by cyclin-dependent kinase 9 (CDK9) is crucial for transcriptional regulation, and acute inhibition of CDK9 results in the rapid downregulation of genes with short-lived transcripts and labile proteins. Multiple non-selective CDK9 inhibitors have progressed clini...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013796 | Pride
A selective cdk9 inhibitor Azd4573 Targets mcl-1 
ProteomicsEpendymoma instructs cranial haematopoiesis and immunotolerance
ZFTA-RELA ependymoma presents a significant clinical challenge due to the lack of effective treatments, driving the need to explore novel immunotherapeutic strategies. Recent studies have identified the skull bone marrow as a source of meningeal immune cells critical for central nervous system (CNS)...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-01 | PXD058239 | Pride
Immune surveillance Skull bone marrow Csf Hematopoiesis Regulatory t cell Childhood brain tumour Ependymoma 
ProteomicsThe Histone Acetyltransferase MOZ is a Molecular Dependency and Therapeutic Target in NUP98-Rearranged Acute Myeloid Leukemia
NUP98 fusion oncoproteins (FOs) are a hallmark of childhood acute myeloid leukemia (AML), and drive leukemogenesis through liquid-liquid phase separation-mediated nuclear condensate formation. However, the composition and consequences of NUP98 FO-associated condensates are incompletely understood. H...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD058286 | Pride
Histone acetyltransferase Gene fusion Leukemia Nup98 
ProteomicsDNA G-quadruplex structures act as functional elements in - and -globin enhancers
Enhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer-promoter interaction are incompletely understood. G-quadruplex DNA secondary structures (G4s) have recently been shown to co-occur with 3D chromatin interactions, however, t...
ORGANISM(S): Homo sapiens (Human) 
2025-06-05 | PXD063882 | Pride
G-quadruplex structures Enhancers Epigenetics 3d chromatin interactions 
ProteomicsDefining Essential Regulators of Naïve Human Pluripotent Cell Reprogramming
Defining how human pluripotent cell identity is controlled and in particular how naïve pluripotency is acquired during cell reprogramming is crucial for the future applications of pluripotent stem cells. However, the regulatory pathways of naïve cell reprogramming remain incompletely understood. Her...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD023547 | Pride
Pluripotent stem cells  embryonic stem cells  pluripotency  reprogramming  cell state  crispr  polycomb  prc1  histone deacetylases  hdacs. 
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