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ProteomicsNucleolar proteome of the developing brain
To study nucleolar involvement in brain development, the nuclear and nucleolar proteomes from the rat cerebral cortex at postnatal day 7 were analyzed using LC-MS/iTRAQ methodology.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-04-11 | PXD002188 | Pride
Lc-ms Rat Nucleolus Itraq 
ProteomicsDynamics and Structural Features of eEF1A1 and eEF1A2 Paralogs
The aim of the project was to compare the structural dynamics of two tissue-specific variants of human translation elongation factors. eEF1A1 and eEF1A2.
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-05-07 | PXD056814 | Pride
Elogation factors Protein dynamics Hdx-ms Protein structure Split isotopic envelope 
ProteomicsPD-L1 overexpression, SWI/SNF complex Deregulation and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4+ T Cells
The growing tumor avoids recognition and destruction by immune system. During continuous stimulation of tumor infiltrating lymphocytes (TILs) by tumor, TILs become functionally exhausted. Thus, they become unable to kill tumor cells and to produce some cytokines, and lose their ability to proliferat...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-02-17 | PXD026447 | Pride
Cd4+ effector t cells  t cell exhaustion  swi/snf complex  pd-1  pd-l1  pd-l1/pd-1 axis 
ProteomicsInsight into cellular proteome of Lolium multiflorum/Festuca arundinacea introgression forms to decipher crucial mechanisms of cold acclimation in forage grasses
Frost tolerance is the main component of winter-hardiness. To express this trait, plants have to sense low temperature, and respond by activating the process of cold acclimation. The molecular mechanisms of this acclimation have not been fully understood in the agronomically important group of forag...
ORGANISM(S): Festuca arundinacea Lolium multiflorum 
2018-04-10 | PXD007257 | Pride
Lc-msms Grass 2d gel Leaf 
ProteomicsZika virus capsid protein C (ZIKV-C) interactors network mapped by proteomic analysis of human neural stem cells expressing FLAG-tagged C protein
Zika virus is a teratogenic pathogen belonging to the Flaviviridae family. It possesses the ability to penetrate the placenta and affect the brain development of a fetus, resulting in microcephaly and functional impairments. Mechanisms of this neurotoxicity are still unclear, but capsid proteins of ...
ORGANISM(S): Zika virus Homo sapiens (Human) 
2025-07-31 | PXD064412 | Pride
Human neural stem cells Capsid protein Zika virus Protein interaction networks 
ProteomicsProteom-wide analysis of lysine N-homocysteinylation and Hcy-induced proteom changes in Saccharomyces cerevisiae
Hyperhomocysteinemia (HHcy) inhibits growth and is cytotoxic to bacterial, yeast, and mammalian cells. The aim of this study was to determine the changes in proteome of the yeast induced by HHcy and map N-homocysteinylated sites. We identified 38 up- and 32-down-regulated proteins as well as 244 N-h...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) Saccharomyces cerevisiae (Baker's yeast) Equus caballus (Horse) 
2021-04-08 | PXD020821 | Pride
N-homocysteinylation Homocysteine Homocysteine thiolactone Yeast proteome 
ProteomicsPalm oil-rich diet affects murine liver proteome and S-palmitoylome
Palmitic acid (C16:0) is the most abundant saturated fatty acid in animals serving as a substrate in lipid synthesis and β-oxidation, and in the modification of proteins called palmitoylation. The influence of dietary palmitic acid on protein palmitoylation in the context of metabolic processes rema...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-14 | PXD025935 | Pride
S-palmitoylation Neutrophil degranulation Mass spectrometry High-fat diet Palm oil Calfacilitin/tlcd1 
ProteomicsProtein expression in TKI-resistant RCC cells.
Resistance to tyrosine kinase inhibitors is an essential issue concerning targeted therapy in renal cancer. This research focuses on molecular background of resistance to axitinib and sorafenib observed from the very beginning of a standard two-dimensional cell culture in monolayer as well as in thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD002600 | Pride
Kidney cancer Stem cell Mass spectrometry Label free 
ProteomicsAlterations in kernel proteome after infection with Fusarium culmorum in two triticale cultivars with contrasting resistance to Fusarium head blight
Triticale was used as a model to recognize new components of molecular mechanism of resistance to Fusarium head blight (FHB) in cereals. Fusarium-damaged kernels of two lines distinct in levels of resistance to FHB were applied into a proteome profiling using two-dimensional gel electrophoresis (2-D...
ORGANISM(S): Secale cereale x Triticum turgidum subsp. durum 
2018-10-27 | PXD004464 | Pride
Leaf Triticale Lc-msms 
ProteomicsTest HDX experiment on cytochrome C
Cytochrome C from horse heart has became a standard molecule in terms of protein dynamics studies by following the exchange of amide protons at different positions in its seqeunce. Therefore both its structure and dynamics have been well characterised by different methods, like NMR or ETD-based MS. ...
ORGANISM(S): Equus caballus (Horse) 
2024-12-17 | PXD057902 | Pride
Hydrogen-deuterium exchange Mass spectrometry Equus caballus Cytochrome c 
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