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ProteomicsThe human cathelicidin antimicrobial peptide LL-37 promotes the growth of the pulmonary pathogen Aspergillus fumigatus.
Aspergillus fumigatus contributes to invasive and allergic pulmonary disease in immunocompromised individuals. The pulmonary mucus of cystic fibrosis (CF) patients displays elevated levels of the pleiotropic cathelicidin antimicrobial peptide LL-37 and the aim of this work was to assess the effect o...
ORGANISM(S): Aspergillus fumigatus var. fumigatus 
2018-05-22 | PXD008143 | Pride
Growth Ll-37 Aspergillus Antimicrobial 
ProteomicsThe acute host – pathogen interactions between Aspergillus fumigatus and Galleria mellonella
Larvae of the greater wax moth Galleria mellonella are an ideal in vivo model to quickly and easily assess the virulence of a range of human pathogens, to comprehensively analyse the host – pathogen interactome and to reproducibly evaluate the in vivo toxicity and efficacy of anti-microbial agents. ...
ORGANISM(S): Galleria mellonella 
2018-06-21 | PXD008196 | Pride
Galleria aspergillus virulence infection mini-model 
ProteomicsAnalysis of the early cellular and humoral responses of Galleria mellonella larvae to infection by Candida albicans
Galleria mellonella larvae were administered an inoculum of Candida albicans and the cellular and proteomic response to infection over the first 24 hours was monitored. The yeast cell density in infected larvae declined initially but replication commenced six hours post-infection. The hemocyte densi...
ORGANISM(S): Galleria mellonella 
2017-09-06 | PXD006879 | Pride
Candida  galleria Ms/ms Infection Immunity In vivo screening Quantatitive Q-exactive Mini-model 
ProteomicsHumoral Immune response of Galleria mellonella to BCG and APP
The humoral immune response of Galleria mellonella exposed to Mycobacterium bovis BCG (vaccine strain), 1x107 CFU (10 ul inoculum) were injected into the larvae. For low dose BCG challenge, 1x105 CFU (10 ul) were injected. For larval challenge with Actinobacillus pleuropneumoniae (APP), ~1.5x106 CFU...
ORGANISM(S): Galleria mellonella 
2021-09-08 | PXD015250 | Pride
Lc-ms/ms Galleria mellonella Proteomics Innate immune response Humoral Mycobacterium 
ProteomicsProteomic analysis of the processes leading to Madurella mycetomatis grain formation in Galleria mellonella larvae
Mycetoma is a neglected chronic and granulomatous infection primarily associated with the fungal pathogen Madurella mycetomatis. Infection is characterised by the formation of fungal grains inside the infected tissue which commonly result in severe deformity and disability. Currently the biochemical...
ORGANISM(S): Galleria mellonella Madurella mycetomatis 
2020-03-19 | PXD013532 | Pride
Infection Immunity Grain Madurella  galleria In vivo screening Proteomics Mini-model 
ProteomicsExposure of Candida parapsilosis to the silver(I) compound SBC3 induces alterations in the proteome inhibiting protein synthesis and reducing virulence
The antimicrobial properties of silver have been exploited for many centuries and continue to gain interest in the fight against antimicrobial drug resistance. The broad-spectrum activity and low toxicity of silver has led to its incorporation into a wide range of novel antimicrobial agents, includi...
ORGANISM(S): Candida parapsilosis CDC317 
2022-06-28 | PXD025693 | Pride
Antimicrobial Silver Proteomics Candida 
ProteomicsProteomic responses of Candida albicans to Galleria mellonella larvae hemolymph
This study assessed the development of disseminated candidiasis within Galleria mellonella larvae and characterised the proteomic responses of Candida albicans to larval hemolymph. Infection of larvae with an inoculum of 1 × 106 yeast cell reduced larval viability 24 (53.33 ± 3.33%), 48 (33.33 ± 3....
ORGANISM(S): Candida albicans (Yeast) 
2019-01-17 | PXD011997 | Pride
Candida  galleria Infection Immunity In vivo screening Mini-model 
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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