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ProteomicsComparative Proteomic Analysis Highlights Metabolic Dysfunction in α-synucleinopathy
The synaptic protein α-synuclein is linked through genetics and neuropathology to the pathogenesis of Parkinson’s disease and related disorders. However, the mechanisms by which α-synuclein influences disease onset and progression are incompletely understood. To identify novel pathways and potential...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-09-09 | PXD021312 | Pride
Metabolism Snca Fly Alpha synuclein aggregates Parkinsons disease 
TranscriptomicsIdentification of Neuronal RNA Targets of TDP-43-Containing Ribonucleoprotein Complexes
We identify the RNA targets of TAR DNA-binding protein 43 (TDP-43) from cortical neurons by RNA immunoprecipitation followed by deep sequencing (RIP-seq). We identify 4352 highly enriched RNA targets of TDP-43. We determined that the canonical TDP-43 binding site (TG)n was 55.1-fold enriched in our ...
ORGANISM(S): Rattus norvegicus 
2010-11-04 | E-GEOD-25032 | biostudies-arrayexpress
ProteomicsMembrane-Enriched Brain Proteome Across Stages of Alzheimer's Disease
Previous systems-based proteomic approaches have characterized alterations in protein co-expression networks of unfractionated asymptomatic (AsymAD) and symptomatic Alzheimer’s disease (AD) brains. However, it remains unclear how sample fractionation and sub-proteomic analysis influences the organi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD014376 | Pride
Ad Synaptic proteome Transmembrane proteins 
ProteomicsMiddle-down proteomics reveals RNA binding proteins harbor dense sites of methylation and phosphorylation
Arginine (Arg)-rich RNA-binding proteins play an integral role in RNA metabolism. Post-translational modifications (PTMs) within Arg-rich domains, such as phosphorylation and methylation, regulate multiple steps in RNA metabolism. However, the identification of PTMs within Arg-rich domains with comp...
ORGANISM(S): Homo sapiens (Human) 
2020-01-31 | PXD015208 | Pride
Middle-down Rs protein Etd Decision tree Basic-acidic domains 
ProteomicsQuantitative Proteomics of Acutely Isolated Mouse Microglia Identifies Novel Immune Alzheimer's Disease-related Proteins
Microglia are innate immune cells of the brain that perform phagocytic and inflammatory functions in disease conditions. Transcriptomic studies of acutely-isolated microglia have provided novel insights into their molecular and functional diversity in homeostatic and neurodegenerative disease states...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-18 | PXD009137 | Pride
Cd11b-positive Brain resident microglia 
ProteomicsA U1-70K Protein Interaction Network Reveals a Functional Class of RNA Binding Proteins with Mixed Charge Domains
U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and other proteins of the spliceosome complex are mislocalized to cytoplasmic aggregates in Alzheimer’s disease (AD) brain, yet understanding of the specific mechanisms that cause their aggregation is limited. Many of the RNA binding proteins (RBPs)...
ORGANISM(S): Homo sapiens (Human) 
2018-06-21 | PXD008260 | Pride
U1-70k 
ProteomicsMapping Ubiquitination Sites in Alzheimer's Disease
Alzheimer’s Disease (AD) is characterized by the deposition of protein aggregates such as neurofibrillary tangles (NFTs) and amyloid (Aβ) plaques in the brain. Post-translational modification through ubiquitylationplays critical roles in clearing misfolded protein aggregates. Investig...
ORGANISM(S): Homo sapiens (Human) 
2019-06-25 | PXD009199 | Pride
Ubiquitylome Ad Gg remnant peptides 
ProteomicsCharacterization of detergent insoluble proteome in chronic traumatic encephalopathy
Proteomic sequencing of postmortem human brain can identify dysfunctional proteins that contribute to neurodegenerative disorders like Alzheimer’s disease and frontotemporal dementia. Similar studies in chronic traumatic encephalopathy are limited, but may provide important new insights into this di...
ORGANISM(S): Homo sapiens (Human) 
2017-11-27 | PXD007694 | Pride
Proteostasis Ad Detergent insoluble proteome Human brain cte Alzheimer's disease Dementia pugilistica 
ProteomicsIdentification of novel Kv1.3 channel dependent mechanisms in microglial activation
Pro-inflammatory microglia contribute to disease progression in neuroinflammatory and neurodegenerative diseases. We identify novel Kv1.3 channel-dependent molecular and cellular mechanisms during microglial activation and unravel a Kv1.3-dependent pathway for MHCI-restricted antigen presentation by...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD006753 | Pride
Inflammation Potassium channel Systems pharmacology Microglia Bv2 
ProteomicsProteomic Analysis and Validation of the RGS14 Signaling Interactome in the Mouse Brain
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein with an unusual domain structure that allows it to integrate G protein and mitogen-activated protein kinase (MAPK) signaling pathways. RGS14 mRNA and protein are enriched in brain tissue of rodents and primates. In the adul...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-25 | PXD008461 | Pride
Rgs14 Immunoprecipitation Neuroproteomics Interactome 
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