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ProteomicsA Pilot Proteomic Study of Protein Markers in Autism Spectrum Disorder
Autism spectrum disorder (ASD) diagnosis is increasing, with 1/88 children believed to be affected by the disorder, with a most recent survey suggesting numbers as high as 1/50. Treatment and understanding of ASD causes is a pressing health concern. ASD protein biomarkers may provide clues about ASD...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD000679 | Pride
Autism Cholesterol Apolipoprotein Oxidative stress Biomarkers Asd 
ProteomicsPaenarthrobacter nicotinovorans pAO1 proteome growing on nicotine
The shotgun proteomics approach attempts to identify the proteins expressed by Paenarthrobacter (formerly Arthrobacter) nicotinovorans in the presence of nicotine by using nanoLCMSMS. A total of 792 non redundant proteins were identified when P. nicotinovorans was grown in on citrate, nicotine and c...
ORGANISM(S): Paenarthrobacter Nicotinovorans (ncbitaxon:29320) 
2018-01-25 | MSV000081968 | MassIVE
ProteomicsProteomics Analysis of Lymphoblastoid Cell lines from Patients with Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) consists in the progressive degeneration of motor neurons, caused by mechanisms that are poorly understood and for which there is no cure. Some of the cellular perturbations associated with ALS can be detected in peripheral cells, including lym-phocytes from blood...
ORGANISM(S): Homo sapiens (Human) 
2023-03-12 | PXD040240 | Pride
Amyotopphic lateral sclerosis  proteomics  mass spectrometry  biomarkers 
ProteomicsProteomics Analysis of Human Breast Milk to Assess Breast Cancer Risk
Detection of breast cancer (BC) in young women is challenging because mammography, the most common tool for detecting BC, is not effective on the dense breast tissue characteristic of young women. In addition to the limited means for detecting their BC, young women face a transient increased risk of...
ORGANISM(S): Homo sapiens (Human) 
2017-12-18 | PXD007066 | Pride
Mass spectrometry Breast cancer Breast milk Proteomics Biomarkers 
ProteomicsProteomic analysis of the lake trout (Salvelinus namaycush)
Lake trout are used as bioindicators for toxics exposure in the Great Lakes ecosystem. However, there is no knowledge about lake trout proteome. Here we performed the first lake trout (Salvelinus namaycush) liver proteomics and searched the databases against (NCBI and UniProtKB) Salvelinus, Salmonid...
ORGANISM(S): Salvelinus namaycush 
2019-10-10 | PXD011924 | Pride
Great lakes Evolutionary proteomics Lake trout Fish Protein database Proteogenomics 
ProteomicsTime-dependent analysis of Paenarthrobacter nicotinovorans pAO1 nicotine-related proteome
We used nanoLC–MS/MS in a shotgun proteomics approach in order to identify the proteins expressed by P. nicotinovorans in the presence of nicotine at 3 different time intervals: 7, 10 and 24 hours post inoculation. A total of 915 proteins grouped 584 non-redundant clusters in were identified with an...
ORGANISM(S): Paenarthrobacter nicotinovorans 
2021-06-01 | PXD012577 | Pride
Metabolism Nicotine Citrate medium Paenarthrobacter nicotinovorans 
ProteomicsCan Blood Proteome Diversity Among Fish Species Help Explain Perfluoroalkyl Acid Trophodynamics in Aquatic Food Webs?
Per- and polyfluoroalkyl substances (PFAS) are a diverse family of industrially significant synthetic chemicals infamous for extreme environmental persistence and global environmental distribution. Many PFAS are bioaccumulative and biologically active mainly due to their tendency to bind with variou...
ORGANISM(S): Salvelinus namaycush Alosa pseudoharengus Myoxocephalus thompsonii 
2023-03-11 | PXD039145 | Pride
Shotgun proteomics Apolipoproteins Biomagnification Protein binding Pfas Albumin 
ProteomicsComparative Two-Dimensional Polyacrylamide Gel Electrophoresis (2D-PAGE) of Human Milk to Identify Dysregulated Proteins in Breast Cancer
Breast Cancer (BC) remains a major cause of mortality, and early detection is considered important for reducing BC-associated deaths. Early detection of BC is challenging in young women, due to the limitations of mammography on the dense breast tissue of young women. We recently reported results of ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-25 | PXD009860 | Pride
Mass spectrometry Breast cancer Breast milk 2d-page Proteomics Biomarkers 
ProteomicsProteomic Analysis of the Lake Trout (Salvelinus namaycush) Heart and Blood: the beginning of a comprehensive lake trout protein database
Lake trout (Salvelinus namaycush) are a top-predator species in the Laurentian Great Lakes that are often used as bioindicators of chemical stressors in the ecosystem. Although many studies are done using these fish to determine concentrations of stressors like legacy persistent, bioaccumulative and...
ORGANISM(S): Salvelinus namaycush 
2021-12-30 | PXD023970 | Pride
Proteomics Lake trout Proteogenomics Salvelinus namaycush 
ProteomicsRat atria-2D LC-MS/MS - Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea
To understand the molecular change occurring in the atria during obstructive sleep apnea, we have implemented a rat model of OSA involving the surgical implantation of a tracheal obstructive device, allowing the rats to remain conscious and free-roaming throughout 2 weeks of apnea administration. Ra...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-02-21 | PXD011181 | Pride
Rat Protein dysregulations Atria 
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