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GenomicsDBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
PRJNA1046531 | ENA
ProteomicsThe structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer
The controlled assembly of replication forks is critical for genome stability. The Dbf4-dependent Cdc7 kinase (DDK) initiates replisome assembly by phosphorylating the MCM2-7 replicative helicase at the N-terminal tails of Mcm2, Mcm4 and Mcm6. At present, it remains poorly understood how DDK docks o...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2022-05-31 | PXD031315 | Pride
Cryo-em Ddk Yeast S-phase Dbf4 Molecular dynamics Helicase Origins Cdc7 Helicase activation Kinase Mcm2-7 Dna replication 
OtherDBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
In eukaryotes, CDC7 kinase is crucial for DNA replication initiation and has been involved in fork processing and replication stress response. Human CDC7 requires the binding of either one of two regulatory subunits, DBF4 and DRF1, for its activity. However, it is unclear whether the two regulatory ...
ORGANISM(S): Homo sapiens 
2024-03-28 | GSE248981 | GEO
UnknownDbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.
Not available
S-EPMC2781428 | biostudies-literature
UnknownStructural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase.
Not available
S-EPMC8927117 | biostudies-literature
UnknownDBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
Not available
S-EPMC11169917 | biostudies-literature
UnknownCdc7-Dbf4 is a gene-specific regulator of meiotic transcription in yeast.
Not available
S-EPMC3255779 | biostudies-literature
UnknownCdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation.
Not available
S-EPMC2517636 | biostudies-literature
Unknown'AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7.
Not available
S-EPMC5041073 | biostudies-literature
UnknownEssential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.
Not available
S-EPMC1635350 | biostudies-literature
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