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ProteomicsTRX1-enhanced CAR T cells retain their antitumor functions under pro-oxidative conditions
Immunotherapies with CAR-T cells achieve remarkable success, especially against B-cell malignancies. However, their activity against non-hematopoietic solid tumors is very limited. One central cause of this failure may be that a pro-oxidative tumor microenvironment can downmodulate the activation an...
ORGANISM(S): Homo sapiens (Human) 
2022-11-23 | PXD031073 | Pride
Car t cells Ros Immunosuppression Thioredoxin 1 Cancer immunotherapy Redox regulation 
ProteomicsHomeostatic and Interferon-induced gene expression represent different states of promoter-associated transcription factor ISGF3
Host defense by the innate immune system requires the establishment of antimicrobial states allowing cells to cope with microorganisms before the onset of the adaptive immune response. Interferons (IFN) are of vital importance in the establishment of cell-autonomous antimicrobial immunity. Speed is...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-03 | PXD013209 | Pride
Mouse Bioid Lc-ms/ms 
UnknownRedistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.
Not available
S-EPMC4268254 | biostudies-literature
TranscriptomicsContribution of the STAT1alpha and STAT1beta isoforms to IFN-gamma mediated innate immunity
The transcription factor STAT1 is essential for interferon- (IFN) mediated protective immunity in humans and mice. Two splice isoforms of STAT1, STAT1M-NM-1 and STAT1M-NM-2, differ with regard to a C-terminal transactivation domain, which is absent in STAT1M-NM-2. Dimers of STAT1M-NM-2 are therefore...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-48970 | biostudies-arrayexpress
ModelsBegitt2014 - STAT1 cooperative DNA binding - double GAS polymer model
Begitt2014 - STAT1 cooperative DNA binding - double GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and modelling approaches. The authors have developed two ODE models to describe STAT1...
2024-09-02 | BIOMD0000000501 | BioModels
ModelsBegitt2014 - STAT1 cooperative DNA binding - single GAS polymer model
Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and modelling approaches. The authors have developed two ODE models to describe STAT1...
2024-09-02 | BIOMD0000000500 | BioModels
Manuscript Accepted 
ProteomicsIdentifying interactors of IRF1 and STAT1 during type I and type II interferon treatment using proximity-dependent labeling
Identifying interactors of IRF1 and STAT1 in bone marrow-derived macrophages during type I and type II interferon treatment using the proximity-dependent labeling approach TurboID followed by Mass Spectrometry
ORGANISM(S): Mus musculus (Mouse) 
2024-03-12 | PXD040337 | Pride
Turboid Interactors Irf1 Ifn-ii Ifn-i Stat1 
TranscriptomicsTranscriptome analysis in macrophages treated with type I interferon, heat-killed Listeria monocytogenes, or both.
To define the group of genes which is synergistically induced by cooperative activity of the type I interferon - activated Jak/STAT pathway and other pathways, we treated bone marrow-derived macrophages (BMDM) with heat-killed Listeria (hkL; non-STAT pathways activated), type I interferon alone (onl...
ORGANISM(S): Mus musculus 
2015-06-15 | E-MTAB-3015 | biostudies-arrayexpress
GenomicsChIPseq profile of RNA polymerase (pol II), the p65 subunit of NFkB, STAT1 and STAT2 in bone marrow derived macrophages after treatment with IFNb, heat-killed Listeria monocytogenes (hkL), or both.
Using ChIP-Seq analysis we define genes induced in macrophages through synergistic transcriptional activation by NFkB and the IFNb-activated transcription factor ISGF3.
ORGANISM(S): Mus musculus 
2015-06-15 | E-MTAB-2972 | biostudies-arrayexpress
ProteomicsHomeostatic and Interferon-induced gene expression represent different states of promoter-associated transcription factor ISGF3
Host defense by the innate immune system requires the establishment of antimicrobial states allowing cells to cope with microorganisms before the onset of the adaptive immune response. Interferons (IFN) are of vital importance in the establishment of cell-autonomous antimicrobial immunity. Speed is...
ORGANISM(S): Mus Musculus 
2019-07-15 | PXD013251 | panorama
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