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ProteomicsEpitranscriptomic regulation of the oxidative stress response by the radical S-adenosylmethionine methyltransferase RlmN
Bacteria possess elaborate systems to manage reactive oxygen and nitrogen species (ROS) arising from exposure to the mammalian immune system and environmental stresses. Here we report the discovery of an ROS-sensing RNA-modifying enzyme that regulates translation of stress-response proteins in the g...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2023-05-09 | PXD038178 | Pride
E. faecalis Rlmn Oxidative stress Epitranscriptome 
ProteomicsCohesin is involved in transcriptional repression of invasion-related genes
The most virulent human malaria parasite, Plasmodium falciparum, has a complex life cycle between its human host and mosquito vector. Each stage is driven by a specific transcriptional program, but with a relatively high ratio of genes to specific transcription factors, it is unclear how genes are a...
ORGANISM(S): Homo sapiens (Human) 
2023-10-04 | PXD035225 | Pride
Plasmodium Smc3 Cohesin 
ProteomicsCytosine methylation of tRNA in Plasmodium falciparum disrupts translational homeostasis to prime for sexual commitment
Malaria parasites have evolved a well-adjusted developmental program to progress through the complex life cycle in the human and mosquito host. Here we identify cytosine methylation of tRNAAsp (GTC) as being critical to maintain stable protein synthesis under cellular stress. Using conditional knock...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-02-13 | PXD024769 | Pride
Epitranscriptomics Dmt2 Trna Plasmodium 
ProteomicsAnticodon loop remodeling and D-stem shape drive the specific recognition of ANN-decoding tRNAs for t6A modification
N6-threonylcarbamoyladenosine (t6A) is a universal tRNA modification essential for translational fidelity. The modification is installed at position 37 of ANN-decoding tRNAs (N is A, U, G or C) by transfer of a threonylcarbamoyl moiety from a pathway intermediate, catalyzed in bacteria by the TsaBD ...
ORGANISM(S): Escherichia coli 
2026-05-28 | PXD071262 | Pride
Cryo-em Trna Tsab2d2 T6a 
TranscriptomicsProfiling of N6-Adenosine (m6A) Methylation in Arabidopsis thaliana wild-type and fip37-4 LEC1:FIP37
N6-methyladenosine (m6A) represents the most prevalent internal modification on messenger RNA, and requires a multicomponent m6A methyltransferase complex in mammals. How their plant counterparts determine the global m6A modification landscape and its molecular link to plant development remain elusi...
ORGANISM(S): Arabidopsis thaliana 
2016-07-25 | E-GEOD-75506 | biostudies-arrayexpress
ProteomicstRNA modification profile of PA14 transposon insertion mutant library
Transfer RNA (tRNA) modifications have emerged as critical posttranscriptional regulators of gene expression that impact diverse biological and disease processes. While there is extensive knowledge about the enzymes installing the dozens of tRNA modifications – the tRNA epitranscriptome – very littl...
ORGANISM(S): Pseudomonas aeruginosa (strain UCBPP-PA14) 
2025-08-04 | PXD053297 | Pride
Trna modification Ucbpp-pa14 Mrm Lcms 
UnknownCohesin contributes to transcriptional repression of stage-specific genes in the human malaria parasite
Not available
S-SCDT-10_15252-EMBR_202357090 | biostudies-other
ProteomicsPyridoxal phosphate-dependent biosynthesis of aminovaleramide by AvaS in tRNA
In eubacteria, decoding of isoleucine codon AUA requires a specialized tRNA (tRNAIle2) modified with lysidine (k²C) at the anticodon wobble position (C34). This modification converts the tRNA’s decoding specificity from methionine (AUG) to isoleucine (AUA). Recently, aminovaleramide cytidine (ava²C)...
ORGANISM(S): Escherichia coli 
2026-09-14 | PXD076093 | Pride
Qqq Ava2c Rna modification Avas Trna 
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae treated with enediynes compared to gamma radiation
We are investigating the transcriptional response of yeast to treatment with enediynes or gamma radiation, which generate different extents of double or single strand breaks in DNA. We used microarrays to detail the global programme of gene expression underlying the DNA damage response in yeast Expe...
ORGANISM(S): Saccharomyces cerevisiae 
2009-04-23 | E-GEOD-5301 | biostudies-arrayexpress
MetabolomicsRNA modification dynamics during Enterococcus faecalis OG1RF growth
Quantitative analysis of relative levels of RNA modifications in small (primarily tRNA) and large (primarily 16S/23S rRNA) RNAs isolated from Enterococcus faecalis OG1RF across a growth time course in BHI media.
2026-08-20 | MTBLS14602 | MetaboLights
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