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ProteomicsNovel tissue-specific markers revealed by in-depth proteome analysis of human myotendinous junction
Force is transmitted between skeletal muscle and tendon via a highly specialized tissue interface: the myotendinous junction (MTJ). Despite its crucial role in mechano-transduction and involvement in muscle strain injury, knowledge about the molecular composition of the MTJ is incomplete. We perform...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD029307 | Pride
Tendon Proteome Myotendinous junction Lc-ms/ms 
ProteomicsDiscovery of Thymosin beta-4 as a human exerkine and growth factor
Skeletal muscle has emerged as an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Via MS-based proteomics, we identified thymosin beta-4 (TMSB4X) to be the most upregulated secreted protein in the media of contracting C2C12 myotubes...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-15 | PXD024607 | Pride
Contraction Secreted factor Exercise Myokine Growth factor 
ProteomicsInsulin and 5-aminoimidazole-4-carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome
Skeletal muscle is a major contributor to whole-body glucose homeostasis and is an important endocrine organ. To date, few studies have undertaken the large-scale identification of skeletal muscle-derived secreted proteins (myokines), particularly in response to stimuli that activate pathways govern...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-15 | PXD025687 | Pride
Muscle Metabolism Insulin Secretome Aicar Lcms 
ProteomicsMass spectrometry-based analysis of the TBC1D4 interactome in human skeletal muscle
Insulin-stimulated muscle glucose uptake is a key process to alleviate hyperglycemia. This process depends on the redistribution of glucose transporters to the muscle surface membrane following phosphorylation of TBC1D1 and TBC1D4. Genetic evidence from a TBC1D4 loss-of-function mutation in human sk...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-03-01 | PXD026225 | Pride
Muscle Tbc1d4 Diabetes Insulin Interactome Lcms 
ProteomicsIntegrated liver and plasma proteomics in obese mice reveals complex metabolic and immune regulation
Obesity leads to the development of non-alcoholic fatty liver disease (NAFLD) and associated alterations to the plasma proteome. To elucidate the underlying changes associated with obesity, we performed liquid chromatography-tandem mass spectrometry in the liver and plasma of obese leptin-deficient ...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD026821 | Pride
Proteome Ob/ob Obesity Lcms Nafld 
ProteomicsHigh intensity interval training remodels the proteome and acetylome in human skeletal muscle
Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD023084 | Pride
Lysine acetylation Exercise Proteome Skeletal muscle Lcms 
ProteomicsUnraveling the complexities of mitochondrial supercomplexes by mass spectrometry-based proteomics
It is now accepted that mitochondrial respiratory complex subunits assemble in supercomplexes. However, studying supercomplexes has typically relied upon antibody-based protein quantification, often limited to a single subunit per respiratory complex. To provide a deeper insight into mitochondrial p...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-17 | PXD016289 | Pride
Oxidative phosphorylation Mitochondrial supercomplexes Blue native gel Mitochondrial respiratory complexes Protein complex proteomics 
ProteomicsGlobal proteomics reveals distinct muscle adaptations to menstrual cycle phase-based sprint interval training in endurance-trained females
Advances in mass-spectrometry (MS)-based technologies have leveraged our understanding of protein-wide adaptations in human skeletal muscle in response to exercise. However, there is a lack of such data in females, particularly pertaining to already trained females and menstrual cycle phase-based sp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD051852 | Pride
Human Muscle Training Menstrual cycle Lc-ms/ms 
ProteomicsMuscle Cathepsin B benefits Alzheimer's Disease mice
Muscle secretes factors during exercise that enhance cognition. Myokine Cathepsin B (Ctsb) is linked to memory, but its role in neurodegeneration is unclear. Here we show that AAV-vector-mediated Ctsb overexpression in skeletal muscle, in an Alzheimer’s Disease (AD) mouse model (APP/PS1), improved m...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD057069 | Pride
Organ cross-talk Proteomics Alzheimer's disease Cathepsin b 
ProteomicsDysregulated Skeletal Muscle Myosin Super-relaxation in Type II, but Not Type I, Diabetes Mellitus
Skeletal muscle plays a critical role in the onset and development of type II diabetes. However, very few studies have investigated the potential pathogenic role of its most abundant protein, myosin. Hence, here, we aim to define this by focusing on myosin energy-saving state known as super-relaxed ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD053022 | Pride
Proteomics Single muscle fiber Skeletal muscle Diabetes 
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